2-(3-Methoxyphenyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(3-Methoxyphenyl)-1,3-dioxolane
• CAS No.: 19693-78-8
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• DSSTox Substance ID: DTXSID90453788
• Nikkaji Number: J1.092.608D
• Wikidata: Q82275030
• Mol file: 19693-78-8.mol

Synonyms:2-(3-methoxyphenyl)-1,3-dioxolane;19693-78-8;1,3-Dioxolane, 2-(3-methoxyphenyl)-;SCHEMBL18063537;DTXSID90453788;MFCD06208947;AKOS006294758;E89912

Chemical Property of 2-(3-Methoxyphenyl)-1,3-dioxolane

Chemical Property:

• PSA: 27.69000
• LogP: 1.74060
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2OCCO2

Technology Process of 2-(3-Methoxyphenyl)-1,3-dioxolane

There total 7 articles about 2-(3-Methoxyphenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethylene glycol (107-21-1) + 3-methoxy-benzaldehyde (591-31-1) → 2-(3-methoxyphenyl)-1,3-dioxolane (19693-78-8)

Guidance literature:

With C₂₅H₂₀O₁₂S₄*C₂₅H₂₄N₄; In neat (no solvent); at 45 ℃; for 13h; under 15.0015 Torr;

DOI:10.1021/acs.cgd.1c00838

Reference yield: 68.0%

3-methoxy-benzaldehyde (591-31-1) + 2-chloro-ethanol (107-07-3) → 2-(3-methoxyphenyl)-1,3-dioxolane (19693-78-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at -60 ℃; for 1.5h;

DOI:10.1021/ol0613113

Reference yield: 50.0%

orthoformic acid triethyl ester (122-51-0) + 3-methoxy-benzaldehyde (591-31-1) → 2-(3-methoxyphenyl)-1,3-dioxolane (19693-78-8)

Guidance literature:

With tetra-N-butylammonium tribromide; In ethylene glycol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02833

upstream raw materials:

3-(1,3-dioxolan-2-yl)-phenylbromide

sodium methylate

ethylene glycol

3-methoxy-benzaldehyde

Downstream raw materials:

3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)-5-methoxybenzaldehyde

C₁₇H₃₂O₄Si₃

C₁₅H₃₀O₄Si₃

C₁₅H₂₉IO₃Si₃

Refernces

• 1、 -. "Synthesis method of m-methoxybenzyl alcohol". . . Retrieved 2021/06/26.
• 2、 Aliyan, Hamid,Fazaeli, Razieh,Massah, Ahmad Reza,Momeni, Ahmad Reza,Naghash, Hamid Javaherian,Moeinifard, Behzad. "Acetalization of carbonyl compounds catalyzed by bismuth triflate under solvent-free conditions". experimental part. p. 873 - 876. Retrieved 2012/04/05.