N-(1-methyl-1H-benzimidazol-2-yl)benzamide

Base Information

• Chemical Name: N-(1-methyl-1H-benzimidazol-2-yl)benzamide
• CAS No.: 19777-06-1
• Molecular Formula: C15H13N3O
• Molecular Weight: 251.288
• Mol file: 19777-06-1.mol

Synonyms:N-[1-Methyl-1,3-dihydro-benzoimidazol-(2E)-ylidene]-benzamide;2-Benzoylimino-3-methyl-benzimidazolin;

Chemical Property of N-(1-methyl-1H-benzimidazol-2-yl)benzamide

Chemical Property:

• Melting Point: 157 - 158 °C
• PSA: 50.15000
• LogP: 2.24750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-methyl-1H-benzimidazol-2-yl)benzamide

There total 9 articles about N-(1-methyl-1H-benzimidazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-Methylbenzimidazole (1632-83-3) + benzamide (55-21-0,27208-38-4) → N-(1-methyl-1H-benzo[d]imidazol-2-yl)benzamide (19777-06-1)

Guidance literature:

With pyridine; oxygen; copper diacetate; sodium carbonate; In toluene; at 20 ℃; under 760.051 Torr; Heating;

DOI:10.1021/ol902079g

Reference yield: 69.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + iodobenzene (591-50-4) + 2-Amino-1-methylbenzimidazole (1622-57-7) → N-(1-methyl-1H-benzo[d]imidazol-2-yl)benzamide (19777-06-1)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 110 ℃; chemoselective reaction; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c02999

Reference yield: 45.0%

Methyl-phenyl-(5-phenyl-[1,2,4]oxadiazol-3-yl)-amine (116751-85-0) → C16H17N3O2 (116751-86-1) + N-(1-methyl-1H-benzo[d]imidazol-2-yl)benzamide (19777-06-1)

Guidance literature:

In methanol; for 9h; Irradiation;

upstream raw materials:

methanol

Methyl-phenyl-(5-phenyl-[1,2,4]oxadiazol-3-yl)-amine

1-Methylbenzimidazole

benzamide