3H-Pyrazol-3-one, 4-[[(3-ethoxy-4-hydroxyphenyl)methylene]amino]-1,2-dihydro-1,5-dimeth yl-2-phenyl-

Base Information

• Chemical Name: 3H-Pyrazol-3-one, 4-[[(3-ethoxy-4-hydroxyphenyl)methylene]amino]-1,2-dihydro-1,5-dimeth yl-2-phenyl-
• CAS No.: 198488-80-1
• Molecular Formula: C20H21N3O3
• Molecular Weight: 351.405
• Mol file: 198488-80-1.mol

Synonyms:

Chemical Property of 3H-Pyrazol-3-one, 4-[[(3-ethoxy-4-hydroxyphenyl)methylene]amino]-1,2-dihydro-1,5-dimeth yl-2-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3H-Pyrazol-3-one, 4-[[(3-ethoxy-4-hydroxyphenyl)methylene]amino]-1,2-dihydro-1,5-dimeth yl-2-phenyl-

There total 3 articles about 3H-Pyrazol-3-one, 4-[[(3-ethoxy-4-hydroxyphenyl)methylene]amino]-1,2-dihydro-1,5-dimeth yl-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.45%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) + 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) → 4-(3-ethoxy-4-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (198488-80-1)

Guidance literature:

In ethanol; Reflux;

DOI:10.1007/s00044-011-9906-8

Reference yield:

1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one (885-11-0) → 4-(3-ethoxy-4-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (198488-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; zinc / water; ethanol / 0 - 5 °C

2: acetic acid / ethanol / 4 h / Reflux

With acetic acid; zinc; In ethanol; water;

DOI:10.1016/j.bioorg.2018.11.016

Reference yield:

antipyrine (60-80-0) → 4-(3-ethoxy-4-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (198488-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; sodium nitrite / water / 0.33 h / 0 - 5 °C

2: acetic acid; zinc / water; ethanol / 0 - 5 °C

3: acetic acid / ethanol / 4 h / Reflux

With acetic acid; zinc; sodium nitrite; In ethanol; water;

DOI:10.1016/j.bioorg.2018.11.016

upstream raw materials:

4-hydroxy-3-ethoxybenzaldehyde

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one

antipyrine