53824-91-2

Upstream product

• 79-04-9 chloroacetyl chloride 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 

Downstream Products

• 199114-62-0 2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline 
• 228871-30-5 2-phenylaminomethyl-3-methyl-4-(3H)-quinazolinone 
• 228871-31-6 2-(4-methylphenyl)aminomethyl-3-methylquinazolin-4(3H)-one 
• 228871-34-9 2-[(4-chloro-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 228871-35-0 2-[(4-bromo-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 228871-32-7 2-[(4-methoxy-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 228871-33-8 2-[(4-ethyl-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 228871-37-2 2-chloro-N-(3-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-N-phenyl-acetamide 
• 228871-38-3 2-[N-(chloroacetyl)-N-(4-methylphenyl)aminomethyl]-3-methylquinazolin-4(3H)-one 
• 228871-41-8 2-chloro-N-(4-chloro-phenyl)-N-(3-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-acetamide 
• 228871-39-4 2-chloro-N-(4-methoxy-phenyl)-N-(3-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-acetamide 
• 228871-42-9 N-(4-bromo-phenyl)-2-chloro-N-(3-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-acetamide 
• 228871-40-7 2-chloro-N-(4-ethyl-phenyl)-N-(3-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-acetamide 
• 1326546-56-8 2-(2-(4-cyanophenoxy)acetamido)-N-methylbenzamide 

Relevant academic research and scientific papers

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

PRMT5 plays important roles in diverse cellular processes and is upregulated in several human malignancies. Besides, PRMT5 has been validated as an anticancer target in mantle cell lymphoma. In this study, we found a potent and selective PRMT5 inhibitor by performing structure-based virtual screening and hit optimization. The identified compound 17 (IC50 = 0.33 μM) exhibited a broad selectivity against a panel of other methyltransferases. The direct binding of 17 to PRMT5 was validated by surface plasmon resonance experiments, with a Kd of 0.987 μM. Kinetic experiments indicated that 17 was a SAM competitive inhibitor other than the substrate. In addition, 17 showed selective antiproliferative effects against MV4-11 cells, and further studies indicated that the mechanism of cellular antitumor activity was due to the inhibition of PRMT5 mediated SmD3 methylation. 17 may represent a promising lead compound to understand more about PRMT5 and potentially assist the development of treatments for leukemia indications.

PYRAZOLE AMIDE COMPOUNDS AND USES THEREOF

Disclosed is a pyrazole amide compound having fungicidal activity, with a structure shown by the general formula (I): Each of the substituents of the compound being defined as in the description. The compound of the present invention has fungicidal activity, and excellent prevention and controlling effects on diseases, such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, etc., and in particular, a better prevention and controlling effect on cucumber downy mildew and corn rust. Also disclosed is a process for preparing the compound, a fungicidal composition containing the compound of general formula (I) and the use thereof in preventing and controlling disease in crops.

PYRAZOLE AMIDE COMPOUND AND USE THEREOF

Disclosed is a pyrazole amide compound having fungicidal activity, with a structure shown by the general formula (I): Each of the substituents of the compound being defined as in the description. The compound of the present invention has fungicidal activity, and excellent prevention and controlling effects on diseases, such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, etc., and in particular, a better prevention and controlling effect on cucumber downy mildew and corn rust. Also disclosed is a process for preparing the compound, a fungicidal composition containing the compound of general formula(I) and the use thereof in preventing and controlling disease in crops.

4-heteryl-β-lactams : A facile synthesis of 1-aryl-4- [isopropylideneamino/methyl-4(3H)-oxoquinazolin-2-yl] azetidin-2-ones

A facile and efficient synthesis of 4-quinazolinonyl-β-lactams 9 and 10 starting from 2-chloromethylquinazolin-4(3H)-ones 1 is reported.