21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methylhygrolidin

Base Information

• Chemical Name: 21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methylhygrolidin
• CAS No.: 88899-58-5
• Molecular Formula: C₃₇H₆₀O₁₀
• Molecular Weight: 664.877
• Mol file: 88899-58-5.mol

Synonyms:

Chemical Property of 21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methylhygrolidin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methylhygrolidin

There total 2 articles about 21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methylhygrolidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

bafilomycin A1 (88899-55-2) + acetyl chloride (75-36-5) → C37H60O10 (88899-58-5)

Guidance literature:

With pyridine; dmap; for 2.5h; Ambient temperature;

DOI:10.1021/jo9607222

Reference yield:

acetic anhydride (108-24-7) + bafilomycin A1 (88899-55-2) → monoacetyl-bafilomycin-A1 (88899-58-5) + diacetyl-bafilomycin-A1 (88899-57-4)

Guidance literature:

In pyridine;

DOI:10.1016/S0040-4039(00)88394-X

Reference yield: 87.0%

methanol (67-56-1) + C37H60O10 (88899-58-5) → C38H62O10

Guidance literature:

With acetic acid; at 60 ℃; for 8h;

DOI:10.1021/jo9607222

upstream raw materials:

acetic anhydride

bafilomycin A₁

bafilomycin A₁

acetyl chloride