N-Boc-5-hydroxytryptophan Methyl Ester

Base Information

Chemical Name:N-Boc-5-hydroxytryptophan Methyl Ester
CAS No.:203736-17-8
Molecular Formula:C17H22N2O5
Molecular Weight:334.372
Hs Code.:
Mol file:203736-17-8.mol

Synonyms:(2S)-2-tert-Butoxycarbonylamino-3-(5-hydroxy-1H-indol-3-yl)-propionic Acid Methyl Ester;N-Boc-5-hydroxytryptophan methyl ester;

Suppliers and Price of N-Boc-5-hydroxytryptophan Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-5-hydroxytryptophanMethylEster
10g
$ 1540.00

TRC
N-Boc-5-hydroxytryptophanMethylEster
1g
$ 195.00

Total 3 raw suppliers

Chemical Property of N-Boc-5-hydroxytryptophan Methyl Ester

Chemical Property:

Boiling Point:555.9±50.0 °C(Predicted)
PKA:10.02±0.40(Predicted)
PSA：100.65000
Density:1.262±0.06 g/cm3(Predicted)
LogP:2.87320

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-Boc-5-hydroxytryptophanMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Boc-5-hydroxytryptophan Methyl Ester, is an intermediate for the synthesis of 5-(2-Fluoroethoxy)-L-tryptophan (F489510). It can also be used for the preparation of a new series of 4-Aminopyridyl-based lead inhibitors targeting Trypanosoma cruzi CYP51 (TcCYP51).

Technology Process of N-Boc-5-hydroxytryptophan Methyl Ester

There total 6 articles about N-Boc-5-hydroxytryptophan Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 203736-19-0
(S)-2-[3-((S)-2-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-indol-5-yloxycarbonylamino]-3-triisopropylsilanyloxy-propionic acid benzyl ester

: benzyl 2-oxo-1,3-oxazolidine-4-carboxylate

: 203736-17-8,1234880-33-1
(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(97)10618-9

Reference yield: 82.0%

: 67-56-1
methanol

: 24424-99-5
di-tert-butyl dicarbonate

: 4350-09-8,4298-20-8
L-5-HTP

: 203736-17-8,1234880-33-1
(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoate

Guidance literature:: methanol; L-5-HTP; With thionyl chloride; at 0 - 20 ℃; for 12h;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;