3-Phenyloxazolidine

Base Information

• Chemical Name: 3-Phenyloxazolidine
• CAS No.: 20503-92-8
• Molecular Formula: C9H11NO
• Molecular Weight: 149.192
• Hs Code.: 2934999090
• Mol file: 20503-92-8.mol

Synonyms:Oxazolidine, 3-phenyl-;3-Phenyloxazolidine;Oxazolidine,3-phenyl;

Chemical Property of 3-Phenyloxazolidine

Chemical Property:

• Melting Point: 28 °C
• Boiling Point: 94 °C(Press: 1.5 Torr)
• PKA: 4.16±0.40(Predicted)
• PSA: 12.47000
• Density: 1.1056 g/cm3(Temp: 30 °C)
• LogP: 1.54570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyloxazolidine

There total 13 articles about 3-Phenyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Anilinoethanol (122-98-5) → 3-phenyl-oxazolidine (20503-92-8)

Guidance literature:

In benzene; for 20h; Heating;

DOI:10.1016/S0040-4020(97)00922-8

Reference yield: 76.0%

N,N-dimethyl-aniline (121-69-7,77733-26-7) → 3-phenyl-oxazolidine (20503-92-8) + 1-methyl-1-phenylethyl alcohol (617-94-7) + acetophenone (98-86-2) + N-methyl-N-phenylformamide (93-61-8)

Guidance literature:

With chlorhexidine diphosphanilate; In acetonitrile; at 100 ℃; for 48h; Further byproducts given;

DOI:10.1021/jo00157a020

Reference yield: 18.0%

N-phenyloxazolidin-5-one (115011-74-0) → 3-phenyl-oxazolidine (20503-92-8) + N-methylaniline (100-61-8)

Guidance literature:

With water; In toluene; at 110 ℃; for 3h; Product distribution; Heating; sealed tube;

upstream raw materials:

formaldehyd

2-Anilinoethanol

2-(methylphenylamino)ethyl tert-butyl peroxide

Cumene hydroperoxide

Downstream raw materials:

4-phenyl-octahydro-pyrano[3,2-f][1,4]oxazepine

3,3'-diindolylmethane

diethyl 2,6-dimethyl-1-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

tetrahydrobetacarboline

Refernces

• 1、 You, Mei-Li. "Thermal hazard evaluation of cumene hydroperoxide-metal ion mixture using DSC, TAM III, and GC/MS". . . Retrieved 2016/06/15.
• 2、 Nishiyama, Tomihiro,Kishi, Hiroshi,Kitano, Kouji,Yamada, Fukiko. "One-Pot Synthesis of Ethyl 3-(2-Hydroxyalkyl)aminoalkanoates by Ring Opening of 1,3-Oxazolidines Using Reformatsky Reagent". . p. 1765 - 1768. Retrieved 2007/10/02.