D-Alanyl-L-glutamine

Base Information

Chemical Name:D-Alanyl-L-glutamine
CAS No.:205252-36-4
Molecular Formula:C₈H₁₅N₃O₄
Molecular Weight:217.225
Hs Code.:
DSSTox Substance ID:DTXSID50427208
Nikkaji Number:J964.556J
ChEMBL ID:CHEMBL301458
Mol file:205252-36-4.mol

Synonyms:205252-36-4;D-ALANYL-L-GLUTAMINE;L-Glutamine, D-alanyl-;(2S)-5-amino-2-[[(2r)-2-aminopropanoyl]amino]-5-oxopentanoic acid;(S)-5-Amino-2-((R)-2-aminopropanamido)-5-oxopentanoic acid;H-D-Ala-Gln-OH;D-ALANINE-L-GLUTAMINE;CHEMBL301458;SCHEMBL4274839;DTXSID50427208;MFCD00237837;AKOS010842243;(2S)-2-[(2R)-2-AMINOPROPANAMIDO]-4-CARBAMOYLBUTANOIC ACID

Suppliers and Price of D-Alanyl-L-glutamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
H-D-Ala-Gln-OH
250mg
$ 695.00

Biosynth Carbosynth
H-D-Ala-Gln-OH
500 mg
$ 435.00

Biosynth Carbosynth
H-D-Ala-Gln-OH
250 mg
$ 250.00

Biosynth Carbosynth
H-D-Ala-Gln-OH
100 mg
$ 125.00

Biosynth Carbosynth
H-D-Ala-Gln-OH
2 g
$ 1309.56

Biosynth Carbosynth
H-D-Ala-Gln-OH
1 g
$ 753.00

AK Scientific
D-Alanyl-L-glutamine
2g
$ 2480.00

Total 27 raw suppliers

Chemical Property of D-Alanyl-L-glutamine

Chemical Property:

Boiling Point:615.4±55.0 °C(Predicted)
PKA:3.12±0.10(Predicted)
PSA：135.51000
Density:1.305±0.06 g/cm3(Predicted)
LogP:-0.04000
Storage Temp.:-15°C
XLogP3:-4.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:217.10625597
Heavy Atom Count:15
Complexity:267

Purity/Quality:

99%, ^*data from raw suppliers

H-D-Ala-Gln-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)NC(CCC(=O)N)C(=O)O)N
Isomeric SMILES:C[C@H](C(=O)N[C@@H](CCC(=O)N)C(=O)O)N
Uses H-D-Ala-Gln-OH is used in the synthesis of dipeptides which selectively activate natural killer NK cells.

Technology Process of D-Alanyl-L-glutamine

There total 19 articles about D-Alanyl-L-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 2-bromopropionyl-L-glutamine

: 39537-23-0,281660-34-2,656221-79-3,205252-36-4
alanylglutamine

Guidance literature:: With ammonium hydroxide; at 20 - 60 ℃; for 8h; Autoclave;
DOI:10.1021/op990079w

Reference yield: 65.0%

: 56-85-9,26700-71-0
L-glutamine

: 1142-20-7
N-Cbz-Ala

: 39537-23-0,281660-34-2,656221-79-3,205252-36-4
alanylglutamine

Guidance literature:: N-Cbz-Ala; With hexachloroethane; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 1.5h;

L-glutamine; With potassium hydroxide; In tetrahydrofuran; dichloromethane; water; at 0 ℃; for 2h; pH=13;

With sulfuric acid; hydrogen; more than 3 stages; Product distribution / selectivity;

Reference yield: 60.0%

: N-(O,O-diethyl) phosphoalanine

: 56-85-9,26700-71-0
L-glutamine

: 39537-23-0,281660-34-2,656221-79-3,205252-36-4
alanylglutamine

Guidance literature:: N-(O,O-diethyl) phosphoalanine; With hexachloroethane; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.666667h;

L-glutamine; With potassium hydroxide; In dichloromethane; cyclohexane; water; at 20 ℃; for 0.5h; pH=13;

With nitric acid; trifluoroacetic acid; more than 3 stages; Product distribution / selectivity;