N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE

Base Information

• Chemical Name: N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE
• CAS No.: 205756-46-3
• Molecular Formula: C11H13F2NO
• Molecular Weight: 213.227
• Mol file: 205756-46-3.mol

Synonyms:N-pivaloyl-3,4-difluoroaniline;

Chemical Property of N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE

Chemical Property:

• PSA: 32.59000
• LogP: 3.59890

Purity/Quality:

97% ^*data from raw suppliers

N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE

There total 1 articles about N-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYLPROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pivaloyl chloride (3282-30-2) + 3,4-difluoroaniline (3863-11-4) → N-pivaloyl-3,4-difluoroaniline (205756-46-3)

Guidance literature:

With triethylamine; at 0 - 20 ℃; for 1h;

Reference yield: 77.0%

N-pivaloyl-3,4-difluoroaniline (205756-46-3) + methyl iodide (74-88-4) → 2-tert-butyl-6-fluoro-7-methylbenzoxazole + N-pivaloyl-2-methyl-3,4-difluoroaniline

Guidance literature:

N-pivaloyl-3,4-difluoroaniline; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -60 - -55 ℃; for 1h; Molecular sieve; Inert atmosphere;

methyl iodide; In tetrahydrofuran; cyclohexane; at -40 - 20 ℃; for 3h; Molecular sieve; Inert atmosphere;

DOI:10.1021/op0498969

Reference yield: 65.0%

pyridine-4-carbaldehyde (872-85-5) + N-pivaloyl-3,4-difluoroaniline (205756-46-3) → C17H18F2N2O2 (698395-61-8)

Guidance literature:

N-pivaloyl-3,4-difluoroaniline; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

pyridine-4-carbaldehyde; In tetrahydrofuran; at -78 - 20 ℃;

upstream raw materials:

pivaloyl chloride

3,4-difluoroaniline

Downstream raw materials:

N-[3,4-Difluoro-2-(2,2,2-trifluoro-acetyl)-phenyl]-2,2-dimethyl-propionamide

o-aminotrifluoromethyl ketone

C₁₇H₁₈F₂N₂O₂

N-[3,4-difluoro-2-(4-fluorobenzoyl)phenyl]-2,2-dimethylpropanamide