7,8-Dimethylquinoline

Base Information

• Chemical Name: 7,8-Dimethylquinoline
• CAS No.: 20668-35-3
• Molecular Formula: C11H11N
• Molecular Weight: 157.215
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID00560770
• Nikkaji Number: J1.233.700K
• Wikidata: Q82444365
• Mol file: 20668-35-3.mol

Synonyms:7,8-Dimethylquinoline;20668-35-3;Quinoline, 7,8-dimethyl-;7-methyl-8-methylquinoline;SCHEMBL8404537;DTXSID00560770;MFCD18448797;AKOS006373888;SB67618;BS-22021;SY205272;CS-0089828;EN300-248314;Z1198725580

Chemical Property of 7,8-Dimethylquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 2.85160
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

NLT 98% ^*data from raw suppliers

7,8-Dimethylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C2=C(C=CC=N2)C=C1)C

Technology Process of 7,8-Dimethylquinoline

There total 2 articles about 7,8-Dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

propan-1-ol-3-amine (156-87-6) + 2,3-Dimethylaniline (87-59-2) → 7,8-dimethylquinoline (20668-35-3)

Guidance literature:

With ruthenium trichloride; triphenylphosphine; tin(ll) chloride; In 1,4-dioxane; acetone; at 180 ℃; for 20h;

DOI:10.1002/jhet.5570360510

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + 2,3-Dimethylaniline (87-59-2) → 7,8-dimethylquinoline (20668-35-3)

Guidance literature:

With sulfuric acid; 2,3-dimethylnitrobenzene; iron(II) sulfate;

Reference yield: 94.0%

7,8-dimethylquinoline (20668-35-3) + anthranil (271-58-9) → 2-((7-methylquinolin-8-yl)methylamino)benzaldehyde

Guidance literature:

With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; Trimethylacetic acid; In dichloromethane; at 100 ℃; for 20h; Inert atmosphere;

DOI:10.1002/anie.201602224

upstream raw materials:

glycerol

2,3-Dimethylaniline

propan-1-ol-3-amine

Downstream raw materials:

N-((7-methylquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Refernces

• 1、 Wang, Huai-Wei,Wu, Jia-Xue,Qiao, Yu-Han,Li, Yong-Fei,Li, Da-Cheng,Dou, Jian-Min,Yao, Qing-Xia,Lu, Yi. "RhIII-Catalyzed Direct Heteroarylation of C(sp3)-H and C(sp2)-H Bonds in Heterocycles with N-Heteroaromatic Boronates". supporting information. p. 7177 - 7182. Retrieved 2021/09/18.
• 2、 He, Yimiao,Huang, Lilan,Xie, Limei,Liu, Peng,Wei, Qiongmei,Mao, Fangfang,Zhang, Xuehong,Huang, Jun,Chen, Sijing,Huang, Chusheng. "Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents". . p. 10088 - 10101. Retrieved 2019/08/22.