6-Chloro-2-iodo-9-isopropyl-9H-purine

Base Information

• Chemical Name: 6-Chloro-2-iodo-9-isopropyl-9H-purine
• CAS No.: 207220-30-2
• Molecular Formula: C8H8ClIN4
• Molecular Weight: 322.536
• DSSTox Substance ID: DTXSID50424878
• Nikkaji Number: J1.446.860I
• Wikidata: Q82237643
• ChEMBL ID: CHEMBL337291

Synonyms:6-Chloro-2-iodo-9-isopropyl-9H-purine;207220-30-2;CHEMBL337291;6-chloro-2-iodo-9-(propan-2-yl)-9H-purine;6-chloro-2-iodo-9-propan-2-ylpurine;2,6,9-Trisubstituted purine deriv. 4b;BDBM7504;SCHEMBL2314138;DTXSID50424878;QDWXVKPYLBNGEU-UHFFFAOYSA-N;2-Iodo-6-chloro-9-isopropyl-9H-purine;A1-36155

Chemical Property of 6-Chloro-2-iodo-9-isopropyl-9H-purine

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 321.94822
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N1C=NC2=C1N=C(N=C2Cl)I

Technology Process of 6-Chloro-2-iodo-9-isopropyl-9H-purine

There total 1 articles about 6-Chloro-2-iodo-9-isopropyl-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyl alcohol (67-63-0,8013-70-5) + diethylazodicarboxylate (1972-28-7,218603-74-8) + 6-chloro-2-iodo-(9H)-purine (18552-90-4) → diethyl hydrazodicarboxylate (4114-28-7) + 6-chloro-2-iodo-9-isopropyl-9H-purine (207220-30-2)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at -30 ℃; Title compound not separated from byproducts.;

DOI:10.1039/b312629c

Reference yield: 99.0%

4-methoxy-benzylamine (2393-23-9) + 6-chloro-2-iodo-9-isopropyl-9H-purine (207220-30-2) → (2-iodo-9-isopropyl-9H-purin-6-yl)(4-methoxybenzyl)amine (267885-16-5)

Guidance literature:

With triethylamine; In ethanol; at 60 ℃; for 48h;

DOI:10.1016/j.bmcl.2006.03.060

Reference yield: 98.0%

4-Ethoxyaniline (156-43-4) + 6-chloro-2-iodo-9-isopropyl-9H-purine (207220-30-2) → (2-iodo-9-isopropyl-9H-purin-6-yl)(4-ethoxyphenyl)amine

Guidance literature:

With triethylamine; In ethanol; at 50 ℃;

DOI:10.1021/jm9911130

upstream raw materials:

isopropyl alcohol

diethylazodicarboxylate

6-chloro-2-iodo-(9H)-purine

Downstream raw materials:

(3-iodo-benzyl)-(2-iodo-9-isopropyl-9H-purin-6-yl)-amine

Benzyl-(2-iodo-9-isopropyl-9H-purin-6-yl)-amine

(4-chlorobenzyl)(2-iodo-9-isopropyl-9H-purin-6-yl)amine

(2-iodo-9-isopropyl-9H-purin-6-yl)(4-methoxybenzyl)amine

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