1-(3-hydroxypropyl)cyclohexanol

Base Information

• Chemical Name: 1-(3-hydroxypropyl)cyclohexanol
• CAS No.: 6963-45-7
• Molecular Formula: C9H18 O2
• Molecular Weight: 158.241
• Mol file: 6963-45-7.mol

Synonyms:1-Hydroxycyclohexanepropanol;NSC 53782

Chemical Property of 1-(3-hydroxypropyl)cyclohexanol

Chemical Property:

• Vapor Pressure: 0.000776mmHg at 25°C
• Boiling Point: 272.6°C at 760 mmHg
• Flash Point: 127.2°C
• Density: 1.031g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-hydroxypropyl)cyclohexanol

There total 25 articles about 1-(3-hydroxypropyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-oxaspiro[4.5]decan-2-one (699-61-6) → 1-(3-hydroxypropyl)-cyclohexanol (6963-45-7)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 36h; Ambient temperature;

DOI:10.1021/jo00019a019

Reference yield: 80.0%

4-butanolide (96-48-0) + pentamethylenebis(magnesium bromide) (23708-48-7) → 1-(3-hydroxypropyl)-cyclohexanol (6963-45-7)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jo01298a016

Reference yield: 71.0%

n-butyllithium (109-72-8,29786-93-4) + 1-iodopropan-3-ol (627-32-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-butyl-cyclohexanol (5445-30-7) + 1-(3-hydroxypropyl)-cyclohexanol (6963-45-7)

Guidance literature:

1-iodopropan-3-ol; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

cyclohexanone; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Further stages.;

DOI:10.1021/ol701947y

upstream raw materials:

1-(3-hydroxyprop-1-yn-1-yl)cyclohexan-1-ol

1-[3-(1-Ethoxy-ethoxy)-propyl]-cyclohexanol

trimethylene oxide

cyclohexanone

Downstream raw materials:

1-oxaspiro<4,5>decane

3-(cyclohex-1-en-1-yl)propan-1-ol

1-(4-nitro-benzoyloxy)-1-[3-(4-nitro-benzoyloxy)-propyl]-cyclohexane

3-(cyclohex-1-enyl)propyl acetate