Benzenamine, N,N-dimethyl-4-phenoxy-

Base Information

• Chemical Name: Benzenamine, N,N-dimethyl-4-phenoxy-
• CAS No.: 21382-99-0
• Molecular Formula: C14H15NO
• Molecular Weight: 213.279
• DSSTox Substance ID: DTXSID30463008
• Nikkaji Number: J1.078.346A
• Wikidata: Q82287706
• Mol file: 21382-99-0.mol

Synonyms:Benzenamine, N,N-dimethyl-4-phenoxy-;21382-99-0;DTXSID30463008

Chemical Property of Benzenamine, N,N-dimethyl-4-phenoxy-

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 191

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)OC2=CC=CC=C2

Technology Process of Benzenamine, N,N-dimethyl-4-phenoxy-

There total 9 articles about Benzenamine, N,N-dimethyl-4-phenoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-nitrophenyl phenyl ether (620-88-2) → 4-dimethylaminodiphenyl ether (21382-99-0)

Guidance literature:

With formic acid; triethylamine; In water; tert-butyl alcohol; at 100 ℃; for 30h;

DOI:10.1002/cctc.201701617

Reference yield: 23.0%

4-phenoxyanilin (139-59-3) + methyl iodide (74-88-4) → para-phenoxy-N-methylaniline (72920-03-7) + 4-dimethylaminodiphenyl ether (21382-99-0)

Guidance literature:

With triethylamine; In methanol; for 4h; Reflux;

DOI:10.1016/j.bmc.2008.10.088

Reference yield: 13.0%

4-bromo-N,N-dimethylaniline (586-77-6) + phenol (108-95-2,27073-41-2) → N,N,N',N'-tetramethylbenzidine (366-29-0) + 4-dimethylaminodiphenyl ether (21382-99-0)

Guidance literature:

With di-tert-butyl{2′-isopropoxy-[1,1′-binaphthalen]-2-yl}phosphane; sodium hydride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In o-xylene; at 110 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2015.05.104

upstream raw materials:

dimethyl sulfate

4-phenoxyanilin

methyl iodide

4-bromo-N,N-dimethylaniline

Downstream raw materials:

N-hydroxyphthalimide

para-phenoxy-N-methylaniline

4'-Formylaminobiphenyl ether