Technology Process of N,N,N',N'-Tetramethylbenzidine
There total 128 articles about N,N,N',N'-Tetramethylbenzidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-N,N-dimethylaniline;
With
tert.-butyl lithium; manganese(ll) chloride;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
Schlenk technique;
In
tetrahydrofuran; pentane;
at 25 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.joc.8b02834
- Guidance literature:
-
With
palladium dichloride;
In
ethyl acetate;
at 60 ℃;
for 3h;
- Guidance literature:
-
p-toluidine;
With
n-butyllithium; dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
Schlenk technique;
4-dimethylaminophenylmagnesium bromide;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; bis(acetylacetonate)nickel(II); 1,2-dichloro-2-methylpropane;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/ol302688u
