N,4-dimethyl-1,3-thiazol-2-amine

Base Information

• Chemical Name: N,4-dimethyl-1,3-thiazol-2-amine
• CAS No.: 2161-68-4
• Molecular Formula: C5H8N2S
• Molecular Weight: 128.19500
• Hs Code.: 2934100090
• European Community (EC) Number: 831-930-2
• DSSTox Substance ID: DTXSID10355730
• Nikkaji Number: J1.126.256B
• Wikidata: Q82134781
• Mol file: 2161-68-4.mol

Synonyms:2161-68-4;N,4-dimethyl-1,3-thiazol-2-amine;N,4-DIMETHYLTHIAZOL-2-AMINE;METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE;4-Methyl-2-(methylamino)thiazole;methylamino-4-methylthiazole;SCHEMBL259247;DTXSID10355730;DGBNDUXTMUGNGM-UHFFFAOYSA-N;CAA16168;methyl-(4-methylthiazol-2-yl)amine;GEO-04167;MFCD01924766;AKOS008946951;AB10516;SB35437;BS-25418;CS-0138030;FT-0715212;EN300-43198;(4-methylthiazol-2-yl)methanamine, AldrichCPR;N-methyl-N-(4-methyl-1,3-thiazol-2-yl)amine;AB-601/30915021;J-014181;Z48860943

Chemical Property of N,4-dimethyl-1,3-thiazol-2-amine

Chemical Property:

• PSA: 56.39000
• LogP: 0.91510
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 128.04081944
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

97% ^*data from raw suppliers

Methyl-(4-methyl-thiazol-2-yl)-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CSC(=N1)NC

Technology Process of N,4-dimethyl-1,3-thiazol-2-amine

There total 13 articles about N,4-dimethyl-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methylthiazol-2-ylamine (1603-91-4) + dimethyl sulfate (77-78-1) → N,4-dimethyl-1,3-thiazol-2-amine (2161-68-4)

Guidance literature:

With sodium hydroxide; In water; at -5 - 30 ℃; for 6h; Large scale;

Reference yield: 88.0%

1-(methyl)-thiourea (598-52-7) + chloroacetone (78-95-5) → N,4-dimethyl-1,3-thiazol-2-amine (2161-68-4)

Guidance literature:

With pyridine; In methanol; at 20 ℃; for 4h;

DOI:10.1021/jm301475f

Reference yield: 83.0%

1-(methyl)-thiourea (598-52-7) + propargyl bromide (106-96-7) → N,4-dimethyl-1,3-thiazol-2-amine (2161-68-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1055/s-0029-1217700

upstream raw materials:

N-methyl-N-(4-methyl-thiazol-2-yl)-acetamide

1-(methyl)-thiourea

chloroacetone

4-methyl-2-(N-methyl)trifluoroacetamidothiazole

Downstream raw materials:

N-methyl-N-[4-methyl-5-(4-nitro-phenylsulfanyl)-thiazol-2-yl]-acetamide

5-bromo-N,4-dimethylthiazol-2-amine

1,3-dimethyl-1-(4-methyl-thiazol-2-yl)-thiourea

(5-cyclohexyl-4-methyl-thiazol-2-yl)-methyl-amine