TETRAHYDROPYRANYLDIETHYLENEGLYCOL

Base Information

• Chemical Name: TETRAHYDROPYRANYLDIETHYLENEGLYCOL
• CAS No.: 2163-11-3
• Molecular Formula: C9H18O4
• Molecular Weight: 190.24
• Hs Code.: 2932999099
• Mol file: 2163-11-3.mol

Synonyms:2-[2-(oxan-2-yloxy)ethoxy]ethanol;

Chemical Property of TETRAHYDROPYRANYLDIETHYLENEGLYCOL

Chemical Property:

• Boiling Point: 115 °C(Press: 0.75 Torr)
• PKA: 14.36±0.10(Predicted)
• PSA: 47.92000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 0.53850
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99.3% ^*data from raw suppliers

Tetrahydropyranyldiethyleneglycol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: THP-PEG3 is a PEG chain linker with a THP alcohol protecting group. The THP can be removed under acidic conditions. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.
• Uses: Tetrahydropyranyldiethyleneglycol (cas# 2163-11-3) is a compound useful in organic synthesis.

Technology Process of TETRAHYDROPYRANYLDIETHYLENEGLYCOL

There total 3 articles about TETRAHYDROPYRANYLDIETHYLENEGLYCOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,4-dihydro-2H-pyran (110-87-2) + diethylene glycol (111-46-6) → 2-(2-tetrahydropyran-2-yloxyethanoxy)ethanol (2163-11-3)

Guidance literature:

With toluene-4-sulfonic acid; at -10 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ma202587z

Reference yield: 57.0%

TETRAHYDROPYRANE (142-68-7) + diethylene glycol (111-46-6) → 2-(2-tetrahydropyran-2-yloxyethanoxy)ethanol (2163-11-3)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃;

Reference yield:

→ 2-(2-tetrahydropyran-2-yloxyethanoxy)ethanol (2163-11-3)

Guidance literature:

upstream raw materials:

3,4-dihydro-2H-pyran

diethylene glycol

TETRAHYDROPYRANE

Downstream raw materials:

2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethyl 4-methylbenzenesulfonate

2,2'-((8-(15-phenyl-2,5,8,11,14-pentaoxapentadecyl)-8-((2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-ethoxy)methyl)-3,6,10,13-tetraoxapentadecane-1,15-diyl)bis(oxy))bis(tetrahydro-2H-pyran)

diphenyl 2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethyl phosphate

1,3,5-tris(7'-hydroxy-2',5'-dioxa-1'-heptyl)benzene tri(2'-tetrahydropyranyl) ether

Refernces

• 1、 Harada, Norihiro,Nishiyama, Shingo,Kanazawa, Masakatsu,Tsukada, Hideo. "Development of novel PET probes, [18F]BCPP-EF, [ 18F]BCPP-BF, and [11C]BCPP-EM for mitochondrial complex 1 imaging in the living brain". . p. 553 - 561. Retrieved 2013.
• 2、 Liu, Xiao,Tian, Zhicheng,Chen, Chen,Allcock, Harry R.. "Synthesis and characterization of brush-shaped hybrid inorganic/organic polymers based on polyphosphazenes". . p. 1417 - 1426. Retrieved 2012.
• 3、 -. "PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF INFLUENZA VIRUS REPLICATION". Paragraph 00290. . Retrieved 2018/11/22.
• 4、 -. "INHIBITORS OF HEPATITIS C VIRUS POLYMERASE". Paragraph 231; 234. . Retrieved 2016/10/11.