2-Pivalamidoacetic acid

Base Information

Chemical Name:2-Pivalamidoacetic acid
CAS No.:23891-96-5
Molecular Formula:C7H13 N O3
Molecular Weight:159.185
Hs Code.:2924199090
DSSTox Substance ID:DTXSID40368979
Nikkaji Number:J669.210I
Wikidata:Q72471641
Mol file:23891-96-5.mol

Synonyms:N-pivaloylglycine

Suppliers and Price of 2-Pivalamidoacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Pivaloylglycine
100mg
$ 70.00

Crysdot
2-Pivalamidoaceticacid 95+%
5g
$ 589.00

Chemenu
2-Pivalamidoaceticacid 95%
5g
$ 556.00

American Custom Chemicals Corporation
[(2,2-DIMETHYLPROPANOYL)AMINO]ACETIC ACID 95.00%
5G
$ 1379.44

American Custom Chemicals Corporation
[(2,2-DIMETHYLPROPANOYL)AMINO]ACETIC ACID 95.00%
2.5G
$ 1119.71

American Custom Chemicals Corporation
[(2,2-DIMETHYLPROPANOYL)AMINO]ACETIC ACID 95.00%
1G
$ 794.34

AK Scientific
2-Pivalamidoaceticacid
100mg
$ 237.00

Total 22 raw suppliers

Chemical Property of 2-Pivalamidoacetic acid

Chemical Property:

Vapor Pressure:3.14E-06mmHg at 25°C
Melting Point:134-135 °C
Boiling Point:362.2°C at 760 mmHg
PKA:3.62±0.10(Predicted)
Flash Point:172.8°C
PSA：66.40000
Density:1.100±0.06 g/cm3(Predicted)
LogP:0.62420
Storage Temp.:2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:159.08954328
Heavy Atom Count:11
Complexity:169

Purity/Quality:

97% ^*data from raw suppliers

N-Pivaloylglycine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(=O)NCC(=O)O
Uses N-Pivaloylglycine is used in the biological study between dogs and rats. In a high dose toxicity study of pivalic acid (PA), PA caused skeletal muscle disorder in dog, and a significant increase of pivaloyl carnitine (PC) was observed in canine muscle, but not in rat muscle.

Technology Process of 2-Pivalamidoacetic acid

There total 5 articles about 2-Pivalamidoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 42014-50-6
succinimidyl 2,2-dimethylpropionate

: 56-40-6,18875-39-3,25718-94-9
glycine

: 23891-96-5
N-(2,2,2-trimethylacetyl)glycine

Guidance literature:: With sodium hydrogencarbonate; In water; at 20 ℃; for 4h;

Reference yield: 24.0%

: 3282-30-2
pivaloyl chloride

: 56-40-6,18875-39-3,25718-94-9
glycine

: 23891-96-5
N-(2,2,2-trimethylacetyl)glycine

Guidance literature:: With sodium hydroxide; In water; Inert atmosphere; Schlenk technique;
DOI:10.1002/hlca.202100147

Reference yield: 12.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 3282-30-2
pivaloyl chloride

: 23891-96-5
N-(2,2,2-trimethylacetyl)glycine

Guidance literature:: glycine ethyl ester hydrochloride; pivaloyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

With methanol; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b02543