5-Pyrimidinecarboxylic acid, 4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-, methyl ester, (4S)-

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-, methyl ester, (4S)-
CAS No.:218430-63-8
Molecular Formula:C14H14F2N2O4
Molecular Weight:312.273
Hs Code.:
Mol file:218430-63-8.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Pyrimidinecarboxylic acid, 4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-, methyl ester, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-, methyl ester, (4S)-

There total 7 articles about 5-Pyrimidinecarboxylic acid, 4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-, methyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1064689-08-2
(S)-methyl-6-(bromomethyl)-4-(3,4-difluorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 124-41-4
sodium methylate

: 218430-63-8
(S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid methyl ester

Guidance literature:: In methanol; at 60 ℃; for 0.333333h;
DOI:10.1021/jo801463j

Reference yield: 40.0%

: 192574-28-0
5-methoxycarbonyl-4-methoxymethyl-1,2,3,6-tetrahydro-2-oxo-6-(3,4-difluorophenyl)-pyrimidine

: 218430-63-8
(S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid methyl ester

: 220497-99-4
(S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid

Guidance literature:: With Purafect 4000L; tris hydrochloride; 2-amino-2-hydroxymethyl-1,3-propanediol; In water; acetonitrile; at 37 ℃; for 240h; pH=8.5; Enzymatic reaction;
DOI:10.1139/v02-079

Reference yield:

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 34036-07-2
3,4 difluorobenzaldehyde

: 57-13-6
urea

: 218430-63-8
(S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid methyl ester

: 220497-99-4
(S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid

Guidance literature:: 4-methoxyacetoacetic acid methylester; 3,4 difluorobenzaldehyde; urea; With boron trifluoride diethyl etherate; acetic acid; copper(II) oxide; In tetrahydrofuran; Heating;

With subtilistin enzyme; In water; acetonitrile; at 37 ℃; for 240h; Further stages.;
DOI:10.1021/jm990612y