Tta4yaz7R5

Base Information

Chemical Name:Tta4yaz7R5
CAS No.:220009-87-0
Molecular Formula:C₁₄H₁₃FN₄O₃S
Molecular Weight:336.347
Hs Code.:
UNII:TTA4YAZ7R5
Nikkaji Number:J2.014.346K
ChEMBL ID:CHEMBL335849
Mol file:220009-87-0.mol

Synonyms:TTA4YAZ7R5;UNII-TTA4YAZ7R5;PNU-176665;N-(((5S)-3-(3-Fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide;220009-87-0;Acetamide, N-(((5S)-3-(3-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-;CHEMBL335849;SCHEMBL8137818;(5S)-3-[3-Fluoro-4-(1,3,4-thiadiazole-2-yl)phenyl]-5alpha-(acetylaminomethyl)oxazolidine-2-one

Suppliers and Price of Tta4yaz7R5

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Tta4yaz7R5

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:336.06923963
Heavy Atom Count:23
Complexity:469

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)C3=NN=CS3)F
Isomeric SMILES:CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)C3=NN=CS3)F

Technology Process of Tta4yaz7R5

There total 6 articles about Tta4yaz7R5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181997-31-9
N-{[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

: 220009-87-0
(S)-N-[[3-[3-Fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaNO₂; aq. HCl / 1.5 h / 0 °C

1.2: 72 percent / CuCN / ethyl acetate; H₂O / 0.75 h / 0 °C

2.1: 80 percent / H₂S; triethylamine / dimethylformamide / 100 °C

3.1: tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

4.1: H₂S; pyridine / tetrahydrofuran; CH₂Cl₂

5.1: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

6.1: Heating

With pyridine; hydrogenchloride; hydrogen sulfide; hydrazine hydrate; triethylamine; sodium nitrite; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.018

Reference yield:

: 220010-58-2
N-[[(5S)-3-[3-fluoro-4-nitrile-phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide

: 220009-87-0
(S)-N-[[3-[3-Fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / H₂S; triethylamine / dimethylformamide / 100 °C

2: tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

3: H₂S; pyridine / tetrahydrofuran; CH₂Cl₂

4: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

5: Heating

With pyridine; hydrogen sulfide; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.018

Reference yield:

: 220010-60-6
4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-dithiobenzoic acid methyl ester

: 220009-87-0
(S)-N-[[3-[3-Fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

2: Heating

With hydrazine hydrate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.07.018