2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

Base Information

Chemical Name:2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
CAS No.:220448-02-2
Molecular Formula:C21H19ClN4O2
Molecular Weight:394.85400
Hs Code.:2933990090
UNII:4K8W47WK2L
DSSTox Substance ID:DTXSID10433007
Nikkaji Number:J1.967.022H
Wikipedia:SSR-180,575
Wikidata:Q7393049
Pharos Ligand ID:JNMP6WRAWGX4
ChEMBL ID:CHEMBL517539
Mol file:220448-02-2.mol

Synonyms:7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino(4,5-b)indole-1-acetamide;SSR 180575;SSR180575

Suppliers and Price of 2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide 95+%
1g
$ 3980.00

Matrix Scientific
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide 95+%
250mg
$ 1682.00

Crysdot
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide 95+%
1g
$ 1900.00

American Custom Chemicals Corporation
2-(7-CHLORO-5-METHYL-4-OXO-3-PHENYL-4,5-DIHYDRO-3H-PYRIDAZINO(4,5-B)INDOL-1-YL)-N,N-DIMETHYLACETAMIDE 95.00%
5G
$ 3811.50

Alichem
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
1g
$ 4139.20

Alichem
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
500mg
$ 2450.00

AK Scientific
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
250mg
$ 2320.00

Total 15 raw suppliers

Chemical Property of 2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:612.238oC at 760 mmHg
Flash Point:324.07oC
PSA：60.13000
Density:1.339g/cm3
LogP:3.16150
Storage Temp.:2-8°C
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:394.1196536
Heavy Atom Count:28
Complexity:661

Purity/Quality:

99% ^*data from raw suppliers

2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(C=CC(=C2)Cl)C3=C1C(=O)N(N=C3CC(=O)N(C)C)C4=CC=CC=C4
Recent ClinicalTrials:Dose-effect of SSR180575 in Diabetic Neuropathy

Technology Process of 2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

There total 6 articles about 2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: C₁₇H₁₉ClN₂O₄

: 100-63-0
phenylhydrazine

: 220448-02-2
2-(7-chloro-3-phenyl-5-methyl-4-oxo-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

Guidance literature:: With acetic acid; In ethanol; at 85 ℃; for 15h;
DOI:10.1016/j.bmcl.2014.07.091

Reference yield:

: 220448-66-8
methyl 7-chloro-5-methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetate

: 506-59-2
N,N-dimethylammonium chloride

: 220448-02-2
2-(7-chloro-3-phenyl-5-methyl-4-oxo-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

Guidance literature:: With hydrogenchloride; trimethylaluminum; In dichloromethane; water; toluene;

Reference yield:

: 7-chloro-5-methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-carboxaldehyde

: 220448-02-2
2-(7-chloro-3-phenyl-5-methyl-4-oxo-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / methanol; 1,2-dimethoxyethane; dichloromethane; water

2: hydrogenchloride / methanol; water

3: hydrogenchloride / trimethylaluminum / dichloromethane; water; toluene

With hydrogenchloride; acetic acid; trimethylaluminum; In methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;