N-(4-methoxyphenyl)Glycine

Base Information

• Chemical Name: N-(4-methoxyphenyl)Glycine
• CAS No.: 22094-69-5
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• DSSTox Substance ID: DTXSID40399389
• Nikkaji Number: J759.809B
• Wikidata: Q72517659
• Mol file: 22094-69-5.mol

Synonyms:N-(4-methoxyphenyl)Glycine;22094-69-5;2-(4-methoxyanilino)acetic acid;[(4-methoxyphenyl)amino]acetic acid;DL-4-METHOXYPHENYLGLYCINE;2-((4-Methoxyphenyl)amino)acetic acid;2-[(4-methoxyphenyl)amino]acetic acid;(4-Methoxyphenylamino)acetic acid;p-methoxyphenylglycine;Oprea1_222791;(4-methoxyanilino)acetic acid;SCHEMBL1797197;DTXSID40399389;AMY39832;2-(4-methoxyphenylamino)acetic acid;MFCD00706051;STL583879;2-((4-Methoxyphenyl)amino)aceticacid;AKOS000101471;LS-09362;CS-0208075;FT-0729702;AF-399/33330033;N-(4-Methoxyphenyl)glycine (Ph(4-OMe)-Gly-OH)

Chemical Property of N-(4-methoxyphenyl)Glycine

Chemical Property:

• Melting Point: 225℃ (sublm)
• Boiling Point: 396.7±27.0 °C(Predicted)
• PKA: 5.02±0.20(Predicted)
• PSA: 58.56000
• Density: 1.258±0.06 g/cm3(Predicted)
• LogP: 1.26470
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Methoxyphenyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NCC(=O)O

Technology Process of N-(4-methoxyphenyl)Glycine

There total 13 articles about N-(4-methoxyphenyl)Glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(4-methoxy)phenylglycine ethyl ester (50845-77-7) → N-(4-methoxyphenyl)glycine (22094-69-5)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1.5h; Reflux;

DOI:10.1002/chem.201904210

Reference yield: 89.0%

4-methoxy-aniline (104-94-9) + ethyl bromoacetate (105-36-2) → N-(4-methoxyphenyl)glycine (22094-69-5)

Guidance literature:

4-methoxy-aniline; ethyl bromoacetate; With silica gel; at 20 ℃; for 0.0666667h; microwave irradiation;

With sodium hydroxide; In ethanol; for 0.166667h; Heating;

DOI:10.3987/COM-05-10574

Reference yield: 82.5%

→ N-(4-methoxyphenyl)glycine (22094-69-5)

Guidance literature:

upstream raw materials:

4-methoxy-aniline

chloroacetic acid

2-Bromoacetyl bromide

ethyl bromoacetate

Downstream raw materials:

N-(4-methoxy-phenyl)-glycine p-anisidide

N-acetyl-N-(4-methoxy-phenyl)-glycine p-anisidide

1,4-bis-(4-methoxy-phenyl)-piperazine-2,6-dione

1-(4-methoxyphenyl)hydantoin