Silane, [(2-azidocyclohexyl)oxy]trimethyl-

Base Information

• Chemical Name: Silane, [(2-azidocyclohexyl)oxy]trimethyl-
• CAS No.: 221110-45-8
• Molecular Formula: C9H19N3OSi
• Molecular Weight: 213.355
• DSSTox Substance ID: DTXSID30450473
• Nikkaji Number: J1.094.975K
• Mol file: 221110-45-8.mol

Synonyms:Silane, [(2-azidocyclohexyl)oxy]trimethyl-;221110-45-8;DTXSID30450473;2-(Trimethylsiloxy)cyclohexyl azide;1-azido-2-(trimethylsiloxy)-cyclohexane

Chemical Property of Silane, [(2-azidocyclohexyl)oxy]trimethyl-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 213.129738772
• Heavy Atom Count: 14
• Complexity: 233

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)OC1CCCCC1N=[N+]=[N-]

Technology Process of Silane, [(2-azidocyclohexyl)oxy]trimethyl-

There total 4 articles about Silane, [(2-azidocyclohexyl)oxy]trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trimethylsilylazide (4648-54-8) + cyclohexane-1,2-epoxide (286-20-4) → 1-azido-2-(trimethylsiloxy)cyclohexane (221110-45-8)

Guidance literature:

tin(II) tartrate; In benzene; for 336h; Ambient temperature;

DOI:10.1246/bcsj.61.1213

Reference yield: 65.0%

trimethylsilylazide (4648-54-8) + cyclohexane-1,2-epoxide (286-20-4) → 1-Chlor-2-trimethylsilyloxy-cyclohexan (51209-80-4,51209-81-5,7742-88-3) + 1-azido-2-(trimethylsiloxy)cyclohexane (221110-45-8)

Guidance literature:

With ytterbium(III) chloride; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.cattod.2011.03.067

Reference yield:

cyclohexene (110-83-8) → 1-azido-2-(trimethylsiloxy)cyclohexane (221110-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Cumene hydroperoxide / dichloromethane / 24 h / 25 °C / Inert atmosphere

2: Laponite-Yb / 1,2-dichloro-ethane / 24 h / 25 °C / Inert atmosphere

With Cumene hydroperoxide; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.cattod.2011.03.067

upstream raw materials:

trimethylsilylazide

cyclohexane-1,2-epoxide

cyclohexene

Downstream raw materials:

(1S,2S)-2-hydroxycyclohexylamine hydrochloride

(1S,2S)-N-(2-hydroxycyclohexyl)acetamide

(1S,2S)-trans-2-aminocyclohexanol