Technology Process of Benzene, 1-[(1-chloro-2-methyl-1-propenyl)sulfinyl]-4-methyl-
There total 3 articles about Benzene, 1-[(1-chloro-2-methyl-1-propenyl)sulfinyl]-4-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
chloromethyl p-tolyl sulfoxide;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.25h;
Inert atmosphere;
With
diethyl chlorophosphate;
In
tetrahydrofuran; hexane;
at -78 - -60 ℃;
for 0.25h;
Inert atmosphere;
acetone;
In
tetrahydrofuran; hexane;
at -60 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/hc.21395
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: LDA / tetrahydrofuran / 0.17 h / -78 °C
1.2: 71 percent / tetrahydrofuran / 0.17 h
2.1: 100 percent / 4-dimethylaminopyridine / pyridine / 13 h / 20 °C
3.1: 53 percent / NaH / dimethylsulfoxide / 3 h
With
dmap; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; pyridine; dimethyl sulfoxide;
1.1: Metallation / 1.2: Addition / 2.1: Acetylation / 3.1: Elimination;
DOI:10.1016/S0040-4020(00)00187-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / 4-dimethylaminopyridine / pyridine / 13 h / 20 °C
2: 53 percent / NaH / dimethylsulfoxide / 3 h
With
dmap; sodium hydride;
In
pyridine; dimethyl sulfoxide;
1: Acetylation / 2: Elimination;
DOI:10.1016/S0040-4020(00)00187-3
