3-Cyano-2-hydroxy-6-methyl-4-phenylpyridine

Base Information

• Chemical Name: 3-Cyano-2-hydroxy-6-methyl-4-phenylpyridine
• CAS No.: 16232-41-0
• Molecular Formula: C13H10 N2 O
• Molecular Weight: 210.235
• Hs Code.: 2933399090
• Mol file: 16232-41-0.mol

Synonyms:Nicotinonitrile,2-hydroxy-6-methyl-4-phenyl- (6CI,8CI); NSC 31908

Chemical Property of 3-Cyano-2-hydroxy-6-methyl-4-phenylpyridine

Chemical Property:

• Vapor Pressure: 5.56E-07mmHg at 25°C
• Boiling Point: 411.5°Cat760mmHg
• Flash Point: 202.7°C
• PSA: 56.91000
• Density: 1.22g/cm³
• LogP: 2.63428

Purity/Quality:

97% ^*data from raw suppliers

3-CYANO-2-HYDROXY-6-METHYL-4-PHENYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Cyano-2-hydroxy-6-methyl-4-phenylpyridine

There total 24 articles about 3-Cyano-2-hydroxy-6-methyl-4-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,6-diphenyl-4-methyl-2-(1H)pyrimidinethione (74360-15-9) + ethyl 2-cyanoacetate (105-56-6) → 6-methyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (16232-41-0)

Guidance literature:

With sodium ethanolate; In ethanol; for 12h; Ambient temperature;

Reference yield: 80.0%

1-Phenylbut-1-en-3-one (122-57-6) + cyanoacetic acid amide (107-91-5) → 6-methyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (16232-41-0)

Guidance literature:

1-Phenylbut-1-en-3-one; cyanoacetic acid amide; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 4.5h;

In water; dimethyl sulfoxide; Reagent/catalyst;

DOI:10.1007/s10593-017-2038-4

Reference yield: 54.0%

benzaldehyde (100-52-7) + ethyl 2-cyanoacetate (105-56-6) + acetone (67-64-1) → 6-methyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (16232-41-0)

Guidance literature:

With pyrrolidine; ammonium acetate; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1002/jhet.2227

upstream raw materials:

6-methyl-2-oxo-4-phenyl-2,3,4,5-tetrahydro-pyridine-3-carbonitrile

3-amino-1-phenylbut-2-en-1-one

sodium ethanolate

ethyl 2-cyanoacetate

Downstream raw materials:

1,6-dimethyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

6-methyl-4-phenyl-pyridin-2-ol

2-chloro-6-methyl-4-phenyl-nicotinonitrile

3-Cyano-6-methyl-4-phenylpyridin