2,2,2-trifluoroethyl octanoate

Base Information

• Chemical Name: 2,2,2-trifluoroethyl octanoate
• CAS No.: 2264-29-1
• Molecular Formula: C10H17F3O2
• Molecular Weight: 226.239
• Mol file: 2264-29-1.mol

Synonyms:

Chemical Property of 2,2,2-trifluoroethyl octanoate

Chemical Property:

• Vapor Pressure: 0.361mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-trifluoroethyl octanoate

There total 5 articles about 2,2,2-trifluoroethyl octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2,2-trifluoroethanol (75-89-8) + n-octanoic acid chloride (111-64-8) → 2,2,2-trifluoroethyl octanoate (2264-29-1)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; 0 deg C to r.t.;

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + p-nitrophenyl-caprylate (1956-10-1) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 2,2,2-trifluoroethyl octanoate (2264-29-1)

Guidance literature:

With phosphate buffer; cetyltrimethylammonim bromide; sodium bromide; at 25 ℃; pH=11.60; Kinetics;

DOI:10.1139/v00-113

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + Octanoic acid (124-07-2) → 2,2,2-trifluoroethyl octanoate (2264-29-1)

Guidance literature:

With silica gel; hydrogen ion exchange resin; for 6h; Reflux;

DOI:10.1016/j.jfluchem.2014.02.006

upstream raw materials:

Octanoic acid

2,2,2-trifluorodiazoethane

2,2,2-trifluoroethanol

n-octanoic acid chloride

Downstream raw materials:

5-heptyl-2,2-dimethyl-4-phenyl-5-(2,2,2-trifluoro-ethoxy)-2,5-dihydro-oxazole

2,2,2-trifluoroethanol

octanoic acid ethyl ester

1,3-di-O-benzyl-2-O-(6-O-octanoyl-β-D-glucopyranosyl)-sn-glycerol

Refernces

• 1、 Duggan, Peter J.,Humphrey, David G.,McCarl, Victoria. "Lipase-catalyzed 1,6-acylation of D-mannitol". . p. 741 - 745. Retrieved 2007/10/03.
• 2、 Nakatani, Takuji,Hiratake, Jun,Yoshikawa, Kazuhiro,Nishioka, Takaaki,Oda, Jun'ichi. "Chemical Inactivation of Lipase in Organic Solvent: A Lipase from Pseudomonas aeruginosa TE3285 is More Like a Typical Serine Enzyme in an Organic Solvent than in Aqueous Media". . p. 1118 - 1123. Retrieved 2007/10/02.