Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-methyl-5-oxo-2-phenyl-, ethyl ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-methyl-5-oxo-2-phenyl-, ethyl ester
• CAS No.: 229484-43-9
• Molecular Formula: C23H19F2N3O3
• Molecular Weight: 423.419
• Mol file: 229484-43-9.mol

Synonyms:

Chemical Property of Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-methyl-5-oxo-2-phenyl-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-methyl-5-oxo-2-phenyl-, ethyl ester

There total 5 articles about Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-methyl-5-oxo-2-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,6-difluorobenzyl chloride (697-73-4) + 5-hydroxy-3-methyl-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester (229485-47-6) → 1-(2,6-difluoro-benzyl)-3-methyl-5-oxo-2-phenyl-1,5-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester + 8-(2,6-difluorobenzyl)-5,8-dihydro-3-methyl-5-oxo-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester (229484-43-9)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00372-4

Reference yield: 70.0%

ethyl 5,8-dihydro-3-methyl-5-oxo-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylate + 2,6-Difluorobenzyl bromide (85118-00-9) → 8-(2,6-difluorobenzyl)-5,8-dihydro-3-methyl-5-oxo-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester (229484-43-9)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; for 18h;

DOI:10.1016/j.bmc.2007.04.065

Reference yield:

2,6-difluorobenzyl chloride (697-73-4) + 5-hydroxy-3-methyl-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester (229485-47-6) → 8-(2,6-difluorobenzyl)-5,8-dihydro-3-methyl-5-oxo-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester (229484-43-9)

Guidance literature:

With potassium iodide; potassium carbonate; In water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2,6-difluorobenzyl chloride

5-hydroxy-3-methyl-2-phenylimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

2,6-Difluorobenzyl bromide

ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

Downstream raw materials:

8-(2,6-difluorobenzyl)-5,8-dihydro-2-[4-(ethylaminocarbonylamino)phenyl]-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

C₃₃H₃₂F₂N₆O₅

8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

2-(4-aminophenyl)-8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

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