8-hydroxy-2-methylquinoline-7-carboxylic acid

Base Information

• Chemical Name: 8-hydroxy-2-methylquinoline-7-carboxylic acid
• CAS No.: 23051-08-3
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.197
• Hs Code.: 2933499090
• Mol file: 23051-08-3.mol

Synonyms:8-Hydroxy-2-methyl-7-quinolinecarboxylic acid;8-hydroxy-7-quinaldine carboxylic acid;2-methyl-8-hydroxy-7-quinolinecarboxylic acid;2-methyl-8-hydroxyquinoline-7-carboxylic acid;8-Hydroxy-7-quinaldic acid;8-hydroxyquinaldine-7-carboxylic acid;8-hydroxy-2-methyl-quinoline-7-carboxylic acid;

Chemical Property of 8-hydroxy-2-methylquinoline-7-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.46E-06mmHg at 25°C
• Boiling Point: 376.4oC at 760 mmHg
• Flash Point: 181.5oC
• PSA: 70.42000
• Density: 1.41g/cm3
• LogP: 1.94700

Purity/Quality:

99% ^*data from raw suppliers

8-HYDROXY-2-METHYLQUINOLINE-7-CARBOXYLIC ACID 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-hydroxy-2-methylquinoline-7-carboxylic acid

There total 5 articles about 8-hydroxy-2-methylquinoline-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-methyl-8-quinolinol (826-81-3) + carbon dioxide (124-38-9,18923-20-1) → 8-hydroxy-2-methylquinoline-7-carboxylic acid (23051-08-3)

Guidance literature:

2-methyl-8-quinolinol; With potassium tert-butylate; In tetrahydrofuran; for 1h; Reflux;

carbon dioxide; In N,N-dimethyl-formamide; at 115 - 120 ℃; for 3h;

DOI:10.1016/j.molstruc.2012.08.009

Reference yield:

2-methyl-8-quinolinol (826-81-3) → 8-hydroxy-2-methylquinoline-7-carboxylic acid (23051-08-3)

Guidance literature:

With potassium carbonate; In CO₂;

Reference yield:

2-methyl-8-quinolinol (826-81-3) + carbon monoxide (201230-82-2) → 8-hydroxy-2-methylquinoline-7-carboxylic acid (23051-08-3)

Guidance literature:

With potassium hydroxide;

DOI:10.1016/j.bmc.2008.02.065

upstream raw materials:

2-methyl-8-quinolinol

carbon dioxide

methylammonium carbonate

carbon monoxide