Technology Process of L-Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester
There total 2 articles about L-Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
sulfuric acid;
In
dichloromethane;
for 144h;
- Guidance literature:
-
(S)-N-(benzyloxycarbonyl)valine; methyl iodide;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
isobutene;
With
sulfuric acid;
In
dichloromethane;
for 168h;
DOI:10.1080/00397911.2011.618284
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / 10percent Pd/C / 2-methyl-propan-2-ol / 48 h / 760 Torr
2: bis(2-oxo-3-oxazolidinyl)phosphinic chloride, iPr2NEt / CH2Cl2 / 2 h
3: 93 percent / H2 / 10percent Pd/C / propan-2-ol / 14 h
4: 99 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride, iPr2NEt / CH2Cl2 / 24 h
With
hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
dichloromethane; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/jo00367a018
