Pentanoic acid, 5-chloro-, ethyl ester

Base Information

• Chemical Name: Pentanoic acid, 5-chloro-, ethyl ester
• CAS No.: 2323-81-1
• Molecular Formula: C7H13ClO2
• Molecular Weight: 164.632
• Mol file: 2323-81-1.mol

Synonyms:

Chemical Property of Pentanoic acid, 5-chloro-, ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanoic acid, 5-chloro-, ethyl ester

There total 7 articles about Pentanoic acid, 5-chloro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethanol (64-17-5) + 5-chloro-valeric acid (1119-46-6) → ethyl 5-chloropentanoate (2323-81-1)

Guidance literature:

toluene-4-sulfonic acid; In toluene; at 20 ℃; for 5h; Reflux;

Reference yield: 48.0%

1-Ethoxy-cyclopentylhydroperoxid → ethyl 5-chloropentanoate (2323-81-1)

Guidance literature:

With hydrogenchloride; copper diacetate; In 1-methyl-pyrrolidin-2-one; water; at 25 ℃; for 2h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1039/d1cc03013b

Reference yield: 35.0%

diazoacetic acid ethyl ester (623-73-4) + dimethyl 3-chloropropylboronate → ethyl 5-chloropentanoate (2323-81-1)

Guidance literature:

dimethyl 3-chloropropylboronate; With potassium fluoride; (trifluoromethyl)trimethylsilane; In 1,2-dimethoxyethane; at 20 ℃; for 18h; Inert atmosphere;

With chloro-trimethyl-silane; In 1,2-dimethoxyethane; at -20 - -10 ℃; for 0.333333h; Inert atmosphere;

diazoacetic acid ethyl ester; With methanol; In 1,2-dimethoxyethane; at -20 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.07.141

upstream raw materials:

ethanol

δ-chlorovaleronitrile

5-chloro-valeric acid

5-ethoxy-valeryl chloride

Downstream raw materials:

1,1,5-pentanetricarboxylic acid triethyl ester

5-chloropentan-1-ol

<δ-Aethoxycarbonyl-butyl>-phosphonsaeure-diaethylester

N⁹-(ω-hydroxy-n-amyl)hypoxanthine