N-(4-hydroxyphenyl)-4-methoxybenzamide

Base Information

• Chemical Name: N-(4-hydroxyphenyl)-4-methoxybenzamide
• CAS No.: 23600-48-8
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• DSSTox Substance ID: DTXSID801283287
• Nikkaji Number: J1.747.518E
• Mol file: 23600-48-8.mol

Synonyms:N-(4-hydroxyphenyl)-4-methoxybenzamide;Benzamide, N-(4-hydroxyphenyl)-4-methoxy-;23600-48-8;Oprea1_370419;Oprea1_641165;SCHEMBL5399964;FIPXHELNPLCOPK-UHFFFAOYSA-N;DTXSID801283287;AKOS002270539;N-(4-Hydroxy-phenyl)-4-methoxy-benzamide

Chemical Property of N-(4-hydroxyphenyl)-4-methoxybenzamide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 243.08954328
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)O

Technology Process of N-(4-hydroxyphenyl)-4-methoxybenzamide

There total 9 articles about N-(4-hydroxyphenyl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-amino-phenol (123-30-8) + 4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one (155164-68-4) → N-(4-hydroxyphenyl)-4-methoxybenzamide (23600-48-8)

Guidance literature:

In tetrahydrofuran; at 18 ℃; for 5h;

DOI:10.1055/s-2002-25760

Reference yield: 91.0%

4-methoxy-N-phenylbenzamide (7465-88-5) → N-(4-hydroxyphenyl)-4-methoxybenzamide (23600-48-8)

Guidance literature:

With trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In chloroform; at 20 ℃; for 0.333333h;

DOI:10.1021/jo0260847

Reference yield: 86.0%

carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) + 4-amino-phenol (123-30-8) → 4-(4'-methoxybenzoyloxy)aniline (17838-17-4) + N-(4-hydroxyphenyl)-4-methoxybenzamide (23600-48-8)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis-(diisobutylphosphino)propane; In acetonitrile; at 100 ℃; for 15h; under 10343.2 Torr; chemoselective reaction;

DOI:10.1021/ja508588b

upstream raw materials:

4-amino-phenol

4-methoxy-benzoyl chloride

4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one

4-methoxy-N-phenylbenzamide

Downstream raw materials:

N-(4-Hydroxy-3,5-bis-pyrrolidin-1-ylmethyl-phenyl)-4-methoxy-benzamide

C₁₄H₁₁NO₃

4-amino-N-(4-methylbenzoyl)-2-chlorophenol

4-amino-N-(4-methoxybenzoyl)-2-chlorophenol