4,5-Dichloro-2-(4-methoxybenzoyl)-3(2H)-pyridazinone

Base Information

• Chemical Name: 4,5-Dichloro-2-(4-methoxybenzoyl)-3(2H)-pyridazinone
• CAS No.: 155164-68-4
• Molecular Formula: C12H8 Cl2 N2 O3
• Molecular Weight: 299.113
• DSSTox Substance ID: DTXSID00165840
• Nikkaji Number: J632.893H
• Wikidata: Q83035074
• Mol file: 155164-68-4.mol

Synonyms:155164-68-4;4,5-Dichloro-2-(4-methoxybenzoyl)-3(2H)-pyridazinone;CCRIS 8201;4,5-dichloro-2-(4-methoxybenzoyl)pyridazin-3-one;3(2H)-Pyridazinone, 4,5-dichloro-2-(4-methoxybenzoyl)-;DTXSID00165840;LS-189297;4,5-Dichloro-2-(4-methoxybenzoyl)pyridazin-3(2H)-one

Chemical Property of 4,5-Dichloro-2-(4-methoxybenzoyl)-3(2H)-pyridazinone

Chemical Property:

• Vapor Pressure: 1E-06mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 403.7°Cat760mmHg
• Flash Point: 197.9°C
• PSA: 61.19000
• Density: 1.47g/cm³
• LogP: 2.24720
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 297.9911975
• Heavy Atom Count: 19
• Complexity: 454

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)N2C(=O)C(=C(C=N2)Cl)Cl

Technology Process of 4,5-Dichloro-2-(4-methoxybenzoyl)-3(2H)-pyridazinone

There total 1 articles about 4,5-Dichloro-2-(4-methoxybenzoyl)-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4,5-dichloro-2H-pyridazin-3-one (932-22-9) + 4-methoxy-benzoyl chloride (100-07-2) → 4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one (155164-68-4)

Guidance literature:

With triethylamine; In dichloromethane; at -10 ℃; for 0.166667h;

DOI:10.1055/s-2002-25760

Reference yield: 99.0%

4-amino-phenol (123-30-8) + 4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one (155164-68-4) → N-(4-hydroxyphenyl)-4-methoxybenzamide (23600-48-8)

Guidance literature:

In tetrahydrofuran; at 18 ℃; for 5h;

DOI:10.1055/s-2002-25760

Reference yield: 99.0%

4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one (155164-68-4) + para-methylbenzylamine (104-84-7) → 4-methoxy-N-(4-methylbenzyl)benzamide

Guidance literature:

In dichloromethane; at 22 ℃; for 0.166667h;

DOI:10.1055/s-2002-25760

upstream raw materials:

4,5-dichloro-2H-pyridazin-3-one

4-methoxy-benzoyl chloride

Downstream raw materials:

N-(4-hydroxyphenyl)-4-methoxybenzamide

4-methoxy-N-phenylbenzamide

N-(4-methoxybenzoyl)glycine

2,5-bis(4-methoxyphenyl)-1,3,4-oxadiazole

Refernces

• 1、 Carmellino,Massolini,Pagani,Zani,Leri. "Fungicidal and genotoxic activity of new substituted pyridazinones". . p. 1427 - 1438. Retrieved 2007/10/02.