L-Glutamic acid, N-acetyl-, dimethyl ester

Base Information

• Chemical Name: L-Glutamic acid, N-acetyl-, dimethyl ester
• CAS No.: 2361-99-1
• Molecular Formula: C9H15NO5
• Molecular Weight: 217.21900
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID50461622
• Nikkaji Number: J46.199G
• Mol file: 2361-99-1.mol

Synonyms:2361-99-1;N-Acetylglutamic acid dimethyl ester;L-Glutamic acid, N-acetyl-, dimethyl ester;dimethyl-N-acetyl-glutamate;Glutamic acid, N-acetyl-, dimethyl ester, L-;Dimethyl N-acetyl-L-glutamate;SCHEMBL468764;DTXSID50461622;KAUXXCKARJMDIG-ZETCQYMHSA-N;Dimethyl 2-(acetylamino)pentanedioate #

Chemical Property of L-Glutamic acid, N-acetyl-, dimethyl ester

Chemical Property:

• PSA: 85.19000
• LogP: 0.45760
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 217.09502258
• Heavy Atom Count: 15
• Complexity: 251

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC(CCC(=O)OC)C(=O)OC
• Isomeric SMILES: CC(=O)N[C@@H](CCC(=O)OC)C(=O)OC

Technology Process of L-Glutamic acid, N-acetyl-, dimethyl ester

There total 7 articles about L-Glutamic acid, N-acetyl-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl (2S)-2-[N-acetyl(tert-bytoxy)carbonylamino]pentane-1,5-dioate (500143-67-9) → N-Acetyl-L-glutaminsaeure-dimethylester (2361-99-1)

Guidance literature:

With montmorillonite K-10; In toluene; at 65 ℃; for 3h;

DOI:10.1002/ejoc.200700296

Reference yield: 88.0%

methanol (67-56-1) + N-acetyl-(S)-glutamic acid (1188-37-0) → N-Acetyl-L-glutaminsaeure-dimethylester (2361-99-1)

Guidance literature:

With carbon tetrabromide; for 20h; Heating;

Reference yield: 44.0%

L-glutamic dimethyl ester hydrochloride (23150-65-4) + acetyl chloride (75-36-5) → N-Acetyl-L-glutaminsaeure-dimethylester (2361-99-1)

Guidance literature:

L-glutamic dimethyl ester hydrochloride; With triethylamine; In acetonitrile; at 20 ℃;

acetyl chloride; In acetonitrile; at 20 ℃;

DOI:10.1039/b503900b

upstream raw materials:

diazomethane

N-acetyl-(S)-glutamic acid

dimethyl N-acetylglutamate

L-glutamic acid dimethyl ester