methyl 3,4,5-tribromothiophene-2-carboxylate

Base Information

• Chemical Name: methyl 3,4,5-tribromothiophene-2-carboxylate
• CAS No.: 24647-80-1
• Molecular Formula: C6H3Br3O2S
• Molecular Weight: 378.86400
• Mol file: 24647-80-1.mol

Synonyms:3,4,5-Tribrom-thiophen-2-carbonsaeure-methylester;3,4,5-tribromo-thiophene-2-carboxylic acid methyl ester;Methyl-3,4,5-tribrom-2-thiophencarboxylat;

Chemical Property of methyl 3,4,5-tribromothiophene-2-carboxylate

Chemical Property:

• Melting Point: 117 - 119 °C
• PSA: 54.54000
• LogP: 3.82220

Purity/Quality:

METHYL 3,4,5-TRIBROMOTHIOPHENE-2-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3,4,5-tribromothiophene-2-carboxylate

There total 3 articles about methyl 3,4,5-tribromothiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tetrabromothiophene (3958-03-0) + chloroformic acid ethyl ester (541-41-3) → Methyl-3,4,5-tribrom-2-thiophencarboxylat (24647-80-1)

Guidance literature:

Tetrabromothiophene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

chloroformic acid ethyl ester; In water; at 20 ℃;

DOI:10.1016/j.bmcl.2012.04.057

Reference yield:

3,4,5-tribromo-2-thiophene carboxylic acid (53317-05-8) → Methyl-3,4,5-tribrom-2-thiophencarboxylat (24647-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus (V)-chloride

With phosphorus pentachloride;

Reference yield:

methanol (67-56-1) + 3,4,5-tribromo-thiophene-2-carbonyl chloride (138326-67-7) → Methyl-3,4,5-tribrom-2-thiophencarboxylat (24647-80-1)

Guidance literature:

upstream raw materials:

methanol

3,4,5-tribromo-thiophene-2-carbonyl chloride

3,4,5-tribromo-2-thiophene carboxylic acid

Tetrabromothiophene