62484-15-5

Basic information

• Product Name: 7-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
• Synonyms: 7-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
• CAS NO: 62484-15-5
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 62484-15-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 320℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE(62484-15-5)
• EPA Substance Registry System: 7-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE(62484-15-5)

Safety Data

• Hazardous Substances Data: 62484-15-5(Hazardous Substances Data)

Usage

General Description

7-Methylquinazoline-2,4(1H,3H)-dione is a chemical compound with the molecular formula C9H6N2O2. It is an organic compound belonging to the quinazoline family, which is used in the synthesis of pharmaceuticals and organic materials. 7-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE contains a quinazoline ring with a methyl group at the 7th position and a carbonyl group at the 2nd and 4th positions. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds due to its reactivity and versatile chemical properties. Additionally, it is utilized in the field of medicinal chemistry for the development of new drugs and therapeutic agents.

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 859733-71-4 (2-cyano-5-methyl-phenyl)-urea 
• 115209-84-2 7-methyl-N²,N⁴-di-m-tolyl-quinazoline-2,4-diyldiamine 
• 57-13-6 urea 
• 2305-36-4 4-methylanthranilic acid 
• 590-28-3 potassium cyanate 
• 124-38-9 carbon dioxide 
• 26830-96-6 5-methyl-2-cyanoaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 39549-79-6 2-amino-4-methylbenzamide 
• 26830-95-5 4-methyl-2-nitrobenzonitrile 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 25171-19-1 7-methyl-2,4-dichloroquinazoline 

Relevant articles and documents

[TBDH][HFIP] ionic liquid catalyzed synthesis of quinazoline-2,4(1H,3H)-diones in the presence of ambient temperature and pressure

The utilization of carbon dioxide under mild reaction conditions is an important aspect of the sustainable chemistry point of view. Herein, we prepared three bifunctional protic ionic liquids having 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a cation and an alcohol anions were prepared by simple neutralization of the super base TBD with proton donor alcohols such as hexafluoroisopropanol (HFIP), TFE (2,2,2-Trifluoroethanol) and TFA (2,2,2-Trifluoroacetic acid). These PILs were used as catalysts for chemical fixation of carbon dioxide into quinazoline-2,4(1H,3H)-diones. [TBDH+][HFIP-] protic ionic liquid (PIL) shows very good result compare to other PILs. As a bifunctional ionic liquid, it simultaneously activates 2-aminobenzonitrile as well as CO2 and shows excellent performance for the conversion of 2-aminobenzonitrile to quinazoline-2,4(1H,3H)-diones in presence of CO2 balloon pressure at 35 °C temperature. Moreover, the [TBDH+][HFIP-] PIL can be recycled up to six recycle run.

Method for efficiently catalytically converting carbon dioxide into quinazoline diketone compound by using eutectic solvent under room temperature and atmospheric pressure conditions

The invention relates to a method for efficiently catalytically converting carbon dioxide into quinazoline diketone compounds by using a deep eutectic solvent under room temperature and atmospheric pressure conditions. According to the method, the deep eutectic solvent synthesized by adopting carbon dioxide and o-aminobenzonitrile with different substituent groups as raw materials, adopting ethylene glycol as a hydrogen bond donor, and adopting 1,5-diazabicyclo[4.3.0] non-5-ene (DBN) as a hydrogen bond acceptor, with the molar ratio of the hydrogen bond donor to the hydrogen bond receptor being 1:4, 1:1 and 4:1 is adopted as a catalyst, and the quinazoline diketone compound is synthesized at room temperature under atmospheric pressure for 1-24 h with the ratio of the substrate dosage to the catalyst dosage being 0.4: 3, 0.7: 3 and 1: 3. The invention provides the method for efficiently catalytically converting carbon dioxide into quinazoline diketone compounds by using the eutectic solvent under the conditions of room temperature and atmospheric pressure, and the method is simple and convenient, high in yield, low in cost, low in energy consumption, green and environment-friendly, avoids the use of a transition metal catalyst, and has very high practical application value.

Synthesis method of 2, 4-(1H, 3H)-quinazolinedione and derivatives thereof

The invention discloses a synthesis method of 2, 4-(1H, 3H)-quinazolinedione and derivatives thereof. CO2 and aminobenzonitrile compounds are used as raw materials, and the 2, 4-(1H, 3H)-quinazolinedione and the derivatives thereof are obtained through a reaction by adopting a catalyst as shown in the formula I provided by the invention. Reagents used in the method are cheap and easy to obtain, the product can be synthesized through a one-step method, harsh conditions of high pressure and high temperature are not needed, no metal is left in the whole reaction system, and the used catalyst canbe recycled.