1-Piperidinecarboxylic acid, 3-hydroxy-4-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-, 1,1-dimethylethyl ester, (3R,4R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-hydroxy-4-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-, 1,1-dimethylethyl ester, (3R,4R)-
CAS No.:257938-68-4
Molecular Formula:C27H37NO6
Molecular Weight:471.594
Hs Code.:
Mol file:257938-68-4.mol

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 3-hydroxy-4-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-, 1,1-dimethylethyl ester, (3R,4R)-

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Technology Process of 1-Piperidinecarboxylic acid, 3-hydroxy-4-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-, 1,1-dimethylethyl ester, (3R,4R)-

There total 6 articles about 1-Piperidinecarboxylic acid, 3-hydroxy-4-[4-[3-[(2-methoxyphenyl)methoxy]propoxy]phenyl]-, 1,1-dimethylethyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 188875-36-7
1-(3-Chloro-propoxymethyl)-2-methoxy-benzene

: 257938-67-3
tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate

: 257938-68-4
(3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 66h;
DOI:10.1016/S0014-827X(01)01004-7

Reference yield:

: 257938-67-3
tert-butyl (3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)-piperidine-1-carboxylate

: 257938-68-4
(3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; 1-(3-Chloro-propoxymethyl)-2-methoxy-benzene;

Reference yield:

: 257928-43-1
(R)-4-(4-benzyloxy-phenyl)-1-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine

: 257938-68-4
(3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: BH₃*THF / tetrahydrofuran / 1 h / 20 °C

1.2: 50 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 3 h / 45 °C

2.1: H₂ / Pd/C / methanol / 15 h / 20 °C

3.1: Et₃N / methanol / 3 h / -10 - 0 °C

4.1: 88 percent / K₂CO₃ / dimethylformamide / 66 h / 120 °C

With borane-THF; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0014-827X(01)01004-7