257938-67-3

Basic information

• Product Name: Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol
• Synonyms: Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol;BOC-4-(4-HYROXYPHENYL)-(3S,4S)-3-PIPERIDINOL;(3R,4R)-3-Hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylicacidtert-butylester;1-Piperidinecarboxylicacid,3-hydroxy-4-(4-hydroxyphenyl)-,1,1-dimethylethylester,(3R,4R)-;tert-Butyl(3R,4R)-3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate;(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate
• CAS NO: 257938-67-3
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.35812
• Mol File: 257938-67-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 451.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• PKA: 10.15±0.30(Predicted)
• CAS DataBase Reference: Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol(257938-67-3)
• EPA Substance Registry System: Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol(257938-67-3)

Safety Data

• Hazardous Substances Data: 257938-67-3(Hazardous Substances Data)

Usage

General Description

Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol is a complex chemical compound. Protecting the amine functionalities during organic synthesis and peptide bond formation can be achieved with the use of Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol. The Boc (tert-butyloxycarbonyl) group plays a significant role by obstructing the reactive amine group of the molecule, thereby serving as an effective blocking agent. Additionally, the hydroxyphenyl group, effectively influences the chemical properties of the compound and can enhance its reactivity under various conditions. The 3-piperidinol portion of the molecule can participate in numerous biological interactions, offering potential pharmaceutical benefits. However, specific applications and properties will depend on the exact synthesis and chemical environment of this compound.

Upstream product

• 357608-36-7 tert-butyl 4-[4-(tert-butyl-dimethyl-silanoxy)-phenyl]-3,4-dihydroxy-piperidine-1-carboxylate 
• 357608-35-6 tert-butyl 4-[4-(tert-butyl-dimethyl-silanoxy)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate 
• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 783291-76-9 (3R,4R)-4-(4-Hydroxy-phenyl)-piperidin-3-ol 
• 60-29-7 diethyl ether 
• 257938-64-0 (3R,4R)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol 
• 257928-43-1 (R)-4-(4-benzyloxy-phenyl)-1-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine 

Downstream Products

• 188867-89-2 (3R,4R)-tert-butyl 4-(4-(benzyloxy)phenyl)-3-hydroxypiperidine-1-carboxylate 
• 257938-68-4 (3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 357608-40-3 (R,R)-tert-butyl 3-(4-bromo-benzyloxy)-4-[4-(2-(naphthalen-2-yl)-2-oxo-ethoxy)-phenyl]-piperidine-1-carboxylate 
• 357608-38-9 (R,R)-tert-butyl 3-(4-bromo-benzyloxy)-4-(4-triisopropylsilanyloxy-phenyl)-piperidine-1-carboxylate 

Relevant articles and documents

Selective NR2B Antagonists

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the c

Solid-phase synthesis of aspartic peptidase inhibitors: 3-alkoxy-4-aryl piperidines.

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Process and intermediates for preparation of substituted piperidines

The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof comprising a) hydroboration of a compound of formula 2 A, R1and R2are as herein defined. These comp