257938-67-3

Usage

Uses

Used in Organic Synthesis:
Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol is used as a protecting agent for amine functionalities during organic synthesis. The Boc group serves to block the reactive amine group, preventing unwanted side reactions and allowing for selective reactions to occur.
Used in Peptide Bond Formation:
In the pharmaceutical industry, Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol is used as a protecting agent in the formation of peptide bonds. The Boc group protects the amine group, allowing for the stepwise synthesis of peptides without interference from the amine's reactivity.
Used in Pharmaceutical Development:
Boc-4-(4-Hydroxyphenyl)-(3s,4s)-3-Piperidinol is used as a potential pharmaceutical candidate due to its ability to participate in numerous biological interactions. The hydroxyphenyl group and the 3-piperidinol portion of the molecule contribute to its potential therapeutic applications, although the specific uses will depend on the exact synthesis and chemical environment of the compound.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 783291-76-9 (3R,4R)-4-(4-Hydroxy-phenyl)-piperidin-3-ol 
• 60-29-7 diethyl ether 
• 257938-64-0 (3R,4R)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-piperidin-3-ol 
• 257928-43-1 (R)-4-(4-benzyloxy-phenyl)-1-(1-phenyl-ethyl)-1,2,3,6-tetrahydro-pyridine 
• 357608-36-7 tert-butyl 4-[4-(tert-butyl-dimethyl-silanoxy)-phenyl]-3,4-dihydroxy-piperidine-1-carboxylate 
• 357608-35-6 tert-butyl 4-[4-(tert-butyl-dimethyl-silanoxy)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate 
• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 

Downstream Products

• 188867-89-2 (3R,4R)-tert-butyl 4-(4-(benzyloxy)phenyl)-3-hydroxypiperidine-1-carboxylate 
• 257938-68-4 (3R,4R)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 304025-82-9 (3R,4R)-3-[1-(2-acetylamino-ethyl)-1,2,3,4-tetrahydro-quinolin-7-ylmethoxy]-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 304025-53-4 Ro 661168 

Relevant academic research and scientific papers

Selective NR2B Antagonists

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the c

Process and intermediates for preparation of substituted piperidines

The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof comprising a) hydroboration of a compound of formula 2 A, R1and R2are as herein defined. These comp

Piperidine renin inhibitors: from leads to drug candidates

Non-peptidomimetic renin inhibitors of the piperidine type represent a novel structural class of compounds potentially free of the drawbacks seen with peptidomimetic compounds so far. Synthetic optimization in two structural series focusing on improvement

From peptides to non-peptide peptidomimetics: design and synthesis of new piperidine inhibitors of aspartic peptidases.

[reaction: see text] The 3-alkoxy-4-arylpiperidine inhibitors of aspartic peptidases are shown to be a new type of non-peptide peptidomimetic inhibitor. These piperidines can be designed from peptide-derived inhibitors by use of a structure-generating pro

Solid-phase synthesis of aspartic peptidase inhibitors: 3-alkoxy-4-aryl piperidines.

[reaction: see text]. The 3-alkoxy-4-aryl piperidines are non-peptide peptidomimetic inhibitors of several aspartic peptidases. The solid-phase functionalization of 3,4-disubstituted piperidine scaffolds using a traceless linker strategy is described. Syn