259225-20-2

Upstream product

• 185540-07-2 1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid 
• 140411-20-7 4-iodo-2,6-diisopropylaniline 
• 24544-04-5 2,6-diisopropylbenzenamine 
• 239099-53-7 1-butyl-3-amino-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridine 
• 873194-71-9 methyl 4-amino-3,5-diisopropylbenzoate 
• 664340-51-6 4-amino-3,5-diisopropylbenzenemethanol 
• 259225-36-0 4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-diisopropyl-phenylamine 
• 873194-72-0 [1-butyl-4-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-carbamic acid phenyl ester 

Downstream Products

• 259224-74-3 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-hydroxymethylphenyl)urea 
• 259225-22-4 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-phthalimidomethylphenyl)-urea 
• 259225-21-3 N-[1-butyl-4-(3-methoxyphenyl)-1,2-dihydro-2-oxo-1,8-naphthyridin-3-yl]-N'-(2,6-diisopropyl-4-bromomethylphenyl)urea 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)- on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility

4-Aryl-1,8-naphthyridin-2(1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl)ureido and 3-(hydroxypropoxyphenyl) moieties showed pote

Naphthyridine derivatives

A compound of the formula (I): wherein Ring A is substituted or unsubstituted pyridine ring, Y is substituted or unsubstituted alkyl, etc., R1is hydrogen, or substituted or unsubstituted alkyl, etc., R2is hydrogen or lower alkyl, R3is lower alkyl, Z is 1) —D1—Q [D1is direct bond or divalent C1-8hydrocarbon, etc., Q is hydroxy, carboxyl, etc.], or 2) —D2M—E—W [D2is direct bond or divalent C1-8hydrocarbon, etc., M is oxygen, sulfur, etc., E is direct bond or divalent C1-8hydrocarbon, etc., W is hydroxyl, carboxyl, etc.], or a prodrug thereof, or a pharmaceutically acceptable salt of the same, which exhibits acyl-CoA: cholesterol acyl transferase (ACAT) inhibitory activity, and is useful as an agent for treatment of hyperlipidemia and atherosclerosis.