3,5-Dichloro-4(chloroMethyl)pyridine

Base Information

• Chemical Name: 3,5-Dichloro-4(chloroMethyl)pyridine
• CAS No.: 264123-70-8
• Molecular Formula: C6H4Cl3N
• Molecular Weight: 196.463
• Hs Code.: 2933399090
• Mol file: 264123-70-8.mol

Synonyms:3,5-dichloro-4-chloromethyl-pyridine;3,5-dichloro-4-(triethylsilyl)benzoic acid;Benzoic acid,3,5-dichloro-4-(triethylsilyl);

Chemical Property of 3,5-Dichloro-4(chloroMethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.0233mmHg at 25°C
• Boiling Point: 257.5oC at 760 mmHg
• PKA: 0.16±0.10(Predicted)
• Flash Point: 134.4oC
• PSA: 12.89000
• Density: 1.463g/cm3
• LogP: 3.12720
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

3,5-Dichloro-4-(chloromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloro-4(chloroMethyl)pyridine

There total 3 articles about 3,5-Dichloro-4(chloroMethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3,5-dichloro-4-hydroxymethylpyridine (159783-46-7) → 3,5-dichloro-4-(chloromethyl)pyridine (264123-70-8)

Guidance literature:

3,5-dichloro-4-hydroxymethylpyridine; With thionyl chloride; In dichloromethane; at 20 ℃;

With sodium carbonate; In dichloromethane; water;

DOI:10.1021/jm9002445

Reference yield:

3,5-dichloropyridine-4-carboxylic acid (13958-93-5) → 3,5-dichloro-4-(chloromethyl)pyridine (264123-70-8)

Guidance literature:

3,5-dichloropyridine-4-carboxylic acid; With thionyl chloride; for 18h; Heating / reflux;

In 1,4-dioxane; at 0 - 20 ℃; for 1h;

With thionyl chloride; for 1h; Heating / reflux;

Reference yield:

3,5-dichloropyridine-4-carboxaldehyde (136590-83-5) → 3,5-dichloro-4-(chloromethyl)pyridine (264123-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2: thionyl chloride / 2 h / 80 °C

With sodium tetrahydroborate; thionyl chloride; In methanol;

upstream raw materials:

3,5-dichloropyridine-4-carboxylic acid

3,5-dichloro-4-hydroxymethylpyridine

3,5-dichloropyridine-4-carboxaldehyde

Downstream raw materials:

N-(3,5-dichloro-4-chloromethyl-pyridin-2-yl)-N-methyl-acetamide

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