Thiazolo[5,4-c]pyridine

Base Information

• Chemical Name: Thiazolo[5,4-c]pyridine
• CAS No.: 273-75-6
• Molecular Formula: C6H4N2S
• Molecular Weight: 136.177
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50562784
• Nikkaji Number: J315.889F
• Wikidata: Q82447060
• Mol file: 273-75-6.mol

Synonyms:Thiazolo[5,4-c]pyridine;273-70-1;[1,3]thiazolo[5,4-c]pyridine;MFCD13179629;SCHEMBL10828;DTXSID50562784;FHIMYVFGWKCROK-UHFFFAOYSA-N;AKOS016002844;DS-2352;SB36323;AC-29385;CS-0145519;A847227;J-524919

Chemical Property of Thiazolo[5,4-c]pyridine

Chemical Property:

• Melting Point: 105-106 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 264.282 °C at 760 mmHg
• PKA: 1.78±0.40(Predicted)
• Flash Point: 119.296 °C
• PSA: 54.02000
• Density: 1.369 g/cm³
• LogP: 1.69130
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 136.00951931
• Heavy Atom Count: 9
• Complexity: 107

Purity/Quality:

97% ^*data from raw suppliers

Thiazolo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1N=CS2

Technology Process of Thiazolo[5,4-c]pyridine

There total 12 articles about Thiazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formic acid (64-18-6) + 3-amino-4-mercaptopyridine hydrochloride (139460-11-0) → thiazolo[4,5-c]pyridine (273-75-6)

Guidance literature:

Reflux;

DOI:10.1016/j.tetlet.2010.03.069

Reference yield: 76.0%

formic acid (64-18-6) + 3-(tert-Butoxycarbonylamino)-4-mercaptopyridine (139460-10-9) → thiazolo[4,5-c]pyridine (273-75-6)

Guidance literature:

at 100 ℃; for 4h; Inert atmosphere;

Reference yield: 72.0%

3-(tert-Butoxycarbonylamino)-4-mercaptopyridine (139460-10-9) → thiazolo[4,5-c]pyridine (273-75-6)

Guidance literature:

In formic acid; for 4h; Heating;

DOI:10.3987/COM-04-10071

upstream raw materials:

[1,3]thiazolo[4,5-c]pyridine-2-carboxylic acid

3-nitro-1H-pyridine-4-thione

4-mercapto-3-nitropyridine

3-(tert-Butoxycarbonylamino)-4-mercaptopyridine

Downstream raw materials:

thiazolo[4,5-c]pyridine-N-oxide

C₆H₄N₂OS

2-phenylthiazolo<4,5-c>pyridine

thiazolo[4,5-c]pyridine-2-ylamine