Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Puerarin |
EINECS | 609-296-1 |
CAS No. | 3681-99-0 | Density | 1.642 g/cm3 |
PSA | 160.82000 | LogP | 0.38610 |
Solubility | Soluble in DMSO or DMF. Slightly soluble in water or ethanol | Melting Point |
187-189 °C |
Formula | C21H20O9 | Boiling Point | 791.2 °C at 760 mmHg |
Molecular Weight | 416.384 | Flash Point | 281.5 °C |
Transport Information | N/A | Appearance | Yellow brown Fine Powder |
Safety | 22-24/25-45-36/37/39-26-16 | Risk Codes | 11-34 |
Molecular Structure | Hazard Symbols | F,C | |
Synonyms |
7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one;Hexitol, 1,5-anhydro-1-C-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-;Pneranin;NPI 031G;4H-1-Benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)- (9CI);8-beta-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Sanguinarine citrate;Puerarin 99% (UV);Puerariae P.E.;Pueraria lobata;Pueraria P.E; |
Article Data | 6 |
puerarin
Conditions | Yield |
---|---|
Stage #1: 7-hydroxy-4'-methoxy-8-C-(2,3,4,6-tetra-O-benzyl-β-D-glucocopyranosyl)isoflavone With boron tribromide In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #2: With methanol In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere; | 95% |
6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-3,4,5-tris-trimethyl-silanyloxy-tetrahydro-pyran-2-carbaldehyde
puerarin
Conditions | Yield |
---|---|
Stage #1: 6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-3,4,5-tris-trimethyl-silanyloxy-tetrahydro-pyran-2-carbaldehyde With sodium tetrahydroborate In tetrahydrofuran; ethanol at 0℃; for 0.166667h; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol at 0 - 20℃; for 0.25h; Further stages.; | 75% |
4',7-di-O-benzyldaidzein 8-C-β-D-(2,3,4,6-tetra-O-benzylglucoside)
puerarin
Conditions | Yield |
---|---|
With boron tribromide In dichloromethane at -78 - 20℃; Inert atmosphere; | 71% |
Conditions | Yield |
---|---|
With trimethylsilyl iodide In acetonitrile for 120h; Heating; | A 35% B 39% |
Malonic acid mono-{(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-tetrahydro-pyran-2-ylmethyl} ester
puerarin
Conditions | Yield |
---|---|
With sodium hydroxide; water Ambient temperature; |
Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-2-{2-acetoxy-6-methoxy-3-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenyl}-6-acetoxymethyl-tetrahydro-pyran-3-yl ester
puerarin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: Tl(NO3)3; trimethyl orthoformate / methanol 1.2: 84 percent / aq. HCl / methanol / Heating 2.1: 35 percent / Me3SiI / acetonitrile / 120 h / Heating View Scheme |
B
puerarin
Conditions | Yield |
---|---|
With hydrogenchloride; water In methanol for 1h; Reflux; |
puerarin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium dithionite; trifluoroacetic acid / 11 h / 20 °C 2.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C 3.1: trichlorophosphate / 0.25 h / 10 °C 3.2: 6 h / 70 °C 4.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere 4.2: 0.08 h / 0 °C / Inert atmosphere View Scheme |
puerarin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Molecular sieve 2.1: sodium dithionite; trifluoroacetic acid / 11 h / 20 °C 3.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C 4.1: trichlorophosphate / 0.25 h / 10 °C 4.2: 6 h / 70 °C 5.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere 5.2: 0.08 h / 0 °C / Inert atmosphere View Scheme |
2,3,4,6-tetra-O-benzyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
puerarin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Molecular sieve 2.1: sodium dithionite; trifluoroacetic acid / 11 h / 20 °C 3.1: acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / water / 14 h / 20 °C 4.1: trichlorophosphate / 0.25 h / 10 °C 4.2: 6 h / 70 °C 5.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere 5.2: 0.08 h / 0 °C / Inert atmosphere View Scheme |