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| CAS No.: | 65-23-6 |
|---|---|
| Name: | 3,4-Pyridinedimethanol,5-hydroxy-6-methyl- |
| Molecular Structure: | |
|
|
|
| Formula: | C8H11NO3 |
| Molecular Weight: | 169.18 |
| Synonyms: | Pyridoxol(8CI);2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine;2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;5-Hydroxy-6-methyl-3,4-pyridinedimethanol;Adermin;Bezatin;Pirivitol;Pyridoxin;VB6; |
| EINECS: | 200-603-0 |
| Density: | 1.353 g/cm3 |
| Melting Point: | 214-215 °C(lit.) |
| Boiling Point: | 491.9 °C at 760 mmHg |
| Flash Point: | 251.3 °C |
| Solubility: | 0.1 g/mL at 20 °C in water, clear, colorless |
| Appearance: | crystalline solid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 73.58000 |
| LogP: | 0.08020 |
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Chemistry
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IUPAC Name: 4,5-bis(Hydroxymethyl)-2-methylpyridin-3-ol
Molecular Formula: C8H11NO3
Molecular Weight: 169.177840 g/mol
EINECS: 200-603-0
Classification Code: Drug / Therapeutic Agent; Growth Substances; Human Data; Micronutrients; Vitamin B Complex; Vitamins
Melting Point: 214-215 °C(lit.)
storage temp.: 2-8 °C
solubility: H2O: 0.1 g/mL at 20 °C, clear, colorless
Stability: Stable. Incompatible with strong oxidizing agents.
Index of Refraction: 1.62
Molar Refractivity: 43.95 cm3
Molar Volume: 124.9 cm3
Surface Tension: 69.7 dyne/cm
Density: 1.353 g/cm3
Flash Point: 251.3 °C
Enthalpy of Vaporization: 79.91 kJ/mol
Boiling Point: 491.9 °C at 760 mmHg
Vapour Pressure of Pyridoxine (CAS NO.65-23-6): 1.71E-10 mmHg at 25 °C
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 5143mg/kg/17W (5143mg/kg) | PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC | New England Journal of Medicine. Vol. 309, Pg. 445, 1983. |
| mouse | LD50 | intraperitoneal | 966mg/kg (966mg/kg) | Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977. | |
| mouse | LD50 | intravenous | 545mg/kg (545mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960. | |
| rat | LD50 | intraperitoneal | 1500mg/kg (1500mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964. |
| rat | LD50 | intravenous | 657mg/kg (657mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940. |
| rat | LD50 | oral | 4gm/kg (4000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940. |
| rat | LD50 | subcutaneous | 3100mg/kg (3100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940. |
| women | TDLo | oral | 139mg/kg/5Y-I (139mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS | New England Journal of Medicine. Vol. 311, Pg. 986, 1984. |
| women | TDLo | oral | 2100mg/kg/30D (2100mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: ATAXIA | Neurology. Vol. 35, Pg. 1466, 1985. |
| women | TDLo | oral | 4800mg/kg/17W (4800mg/kg) | PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC | New England Journal of Medicine. Vol. 309, Pg. 445, 1983. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, local anesthetic, paresthesia. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Pyridoxine (CAS NO.65-23-6): UV1350000
Specification
Pyridoxine (CAS NO.65-23-6), its Synonyms are 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl- ; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol ; 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine ; 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine ; 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin ; Adermine . It is crystalline solid.