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Name	Rifaximin	EINECS	617-130-4
CAS No.	80621-81-4	Density	1.366 g/cm³
PSA	198.38000	LogP	6.29580
Solubility	N/A	Melting Point	200-205 °C(dec)
Formula	C₄₃H₅₁N₃O₁₁	Boiling Point	N/A
Molecular Weight	785.891	Flash Point	N/A
Transport Information	N/A	Appearance	Red-orange crystalline powder
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	L 105;L 105(ansamacrolide antibiotic);L 105SV;Rifamycin L 105;Rifamycin L 105SV;Xifaxan;refaximin;	Article Data	1

Rifaximin Synthetic route

: C43H50N3O11(1+)*Br(1-)

: 80621-81-4
rifaximin

Conditions

Conditions	Yield
With ascorbic acid

: 695-34-1
2-Amino-4-methylpyridine

: 80621-81-4
rifaximin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CHCl3 / 2 h / Ambient temperature 2: ascorbic acid View Scheme

: 57375-25-4
3-bromorifamicin S

: 80621-81-4
rifaximin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CHCl3 / 2 h / Ambient temperature 2: ascorbic acid View Scheme

Rifaximin Chemical Properties

Structure of Rifaximin (CAS NO.80621-81-4):

Empirical Formula: C₄₃H₅₁N₃O₁₁
Molecular Weight: 785.8785
Index of Refraction: 1.634
Molar Refractivity: 205.697 cm³
Molar Volume: 575.317 cm³
Polarizability: 81.545×10^-24cm³
Surface Tension: 48.156 dyne/cm
Density: 1.366 g/cm³
Melting Point: 200-205°C(dec)
Physical Appearance: Red-Orange Crystalline Powder
Product Categories: Active Pharmaceutical Ingredients;Antibacterial;Intermediates & Fine Chemicals;Pharmaceuticals
Synonyms of Rifaximin (CAS NO.80621-81-4): (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate ; 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV ; Fatroximin ; Normix ; Rifacol .

Rifaximin Uses

Rifaximin (CAS NO.80621-81-4) is highly effective at preventing and treating traveler's diarrhea among travelers to Mexico, with few side effects and low risk of developing antibiotic resistance. In the United States, Rifaximin has orphan drug status for the treatment of hepatic encephalopathy.

Rifaximin Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 2gm/kg (2000mg/kg)		Drugs of the Future. Vol. 7, Pg. 260, 1982.
rat	LD50	oral	> 2gm/kg (2000mg/kg)		Chemioterapia. Vol. 5, Pg. 263, 1986.

Rifaximin Safety Profile

RTECS: KD1576000

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