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| CAS No.: | 695-34-1 |
|---|---|
| Name: | 4-Methylpyridin-2-amine |
| Article Data: | 25 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H8N2 |
| Molecular Weight: | 108.143 |
| Synonyms: | 4-Picoline, 2-amino-;4-Picolylamine;4-methyl-1H-pyridin-2-amine;RA 1226;2-Amino-4-methylpyridine;2-Pyridinamine,4-methyl-;Methyl-4 amino-2-pyridine;4-Methyl-2-aminopyridine;2-Pyridinamine, 4-methyl-;Pyridine, 2-amino-4-methyl-;4-Methyl-2-pyridinamine;4-Methyl-2-pyridylamine;alpha-Amino-gamma-picoline;4-methylpyridin-2-amine;4-Methyl-pyridin-2-ylamine;2-Amino-4-Methyl pyridine; |
| EINECS: | 211-780-9 |
| Density: | 1.068 g/cm3 |
| Melting Point: | 96-101 °C |
| Boiling Point: | 227.4 °C at 760 mmHg |
| Flash Point: | 114 °C |
| Solubility: | Soluble in water |
| Appearance: | Light yellow to brown flakes |
| Hazard Symbols: |
 T
|
| Risk Codes: | 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25 |
| Safety: | 53-45-60-61-37/39-28A-26-36/37/39 |
| Transport Information: | UN 3086 6.1/PG 1 |
| PSA: | 38.91000 |
| LogP: | 1.55340 |
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2,2-dimethyl-3-(4-methylpyrid-2-yl)-4-oxo-4H-1,3-benzoxazine
A
- 695-34-1
2-Amino-4-methylpyridine
B
- 69-72-7
salicylic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 3h; Heating; | A 94% B n/a |
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 91% |
- 18368-71-3
4-methyl-2-nitropyridine
- 695-34-1
2-Amino-4-methylpyridine
| Conditions | Yield |
|---|---|
| With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; chemoselective reaction; | 90% |
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2-amino-3-chloro-4-methylpyridine
- 695-34-1
2-Amino-4-methylpyridine
| Conditions | Yield |
|---|---|
| With copper; benzoic acid at 150℃; for 1h; | 87.2% |
- 95337-78-3
2-(2,5-dimethyl-pyrrol-1-yl)-4-methyl-pyridine
- 695-34-1
2-Amino-4-methylpyridine
| Conditions | Yield |
|---|---|
| With hydroxylamine hydrochloride In ethanol; water for 24h; Heating; | 82% |
| Conditions | Yield |
|---|---|
| With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction; | 46% |
| Conditions | Yield |
|---|---|
| With sodium amide; xylene | |
| With sodium amide; decalin at 140 - 150℃; |
- 79917-38-7
4-methyl(2-nitroso)pyridine
- 695-34-1
2-Amino-4-methylpyridine
| Conditions | Yield |
|---|---|
| With zinc In acetic acid |
- 76809-23-9
2,2-dimethyl-3-(4-methylpyrid-2-yl)-4-oxo-4H-1,3-benzoxazine
- 695-34-1
2-Amino-4-methylpyridine
| Conditions | Yield |
|---|---|
| With hydrogenchloride Hydrolysis; |
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Consensus Reports
Specification
The IUPAC name of 2-Amino-4-methylpyridine is 4-methylpyridin-2-amine. With the CAS registry number 695-34-1, it is also named as alpha-Amino-gamma-picoline. The product's categories are Variousamine; Fine Chemical & Intermediates; Pyridines, Pyrimidines, Purines and Pteredines; Pyridines Derivates; Pyridines. It is light yellow to brown flakes which is highly toxic and flammable. When heated to decomposition it emits toxic fumes of NOx. So the storage environment should be well- ventilated, low-temperature and dry.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.71; (4)ACD/LogD (pH 7.4): 0.79; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 1.49; (8)ACD/KOC (pH 7.4): 47.27; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.574; (13)Molar Refractivity: 33.4 cm3; (14)Molar Volume: 101.2 cm3; (15)Polarizability: 13.24×10-24 cm3; (16)Surface Tension: 46.9 dyne/cm; (17)Enthalpy of Vaporization: 46.39 kJ/mol; (18)Vapour Pressure: 0.0778 mmHg at 25°C; (19)Tautomer Count: 2; (20)Exact Mass: 108.068748; (21)MonoIsotopic Mass: 108.068748; (22)Topological Polar Surface Area: 38.9; (23)Heavy Atom Count: 8; (24)Complexity: 72.9.
Uses of 2-Amino-4-methylpyridine: It is used as pharmaceutical intermediate. And it also can react with 2-bromo-1-thiophen-2-yl-ethanone to get 7-methyl-2-[2]thienyl-imidazo[1,2-a]pyridine. This reaction needs solvent ethanol by heating. The reaction time is 4.0 hours. The yield is 75%.
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When you are using this chemical, please be cautious about it as the following:
It is not only toxic by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. And it is very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. What's more, this chemical cam cause burns and may cause harm to the unborn child. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) This material and its container must be disposed of as hazardous waste. Avoid release to the environment. Refer to special instructions / safety data sheets.
People can use the following data to convert to the molecule structure.
1. SMILES:n1ccc(cc1N)C
2. InChI:InChI=1/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
3. InChIKey:ORLGLBZRQYOWNA-UHFFFAOYAS
The following are the toxicity data which has been tested.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | skin | 500mg/kg (500mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 841, 1986. | |
| mouse | LD50 | intravenous | 39mg/kg (39mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Annales Pharmaceutiques Francaises. Vol. 26, Pg. 345, 1968. |
| mouse | LD50 | subcutaneous | 64mg/kg (64mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 227S, 1957. |
| rat | LD50 | oral | 200mg/kg (200mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 841, 1986. | |
| rat | LD50 | subcutaneous | 160mg/kg (160mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 227, Pg. 234, 1955. |