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Name Ronidazole
EINECS231-675-1
CAS No. 7681-76-7
Density1.65 g/cm³
PSA115.96000
LogP1.14710
SolubilityN/A
Melting Point167-169°
FormulaC₆H₈N₄O₄
Boiling Point502.3 °C at 760 mmHg
Molecular Weight200.154
Flash Point257.6 °C
Transport InformationN/A
AppearanceN/A
Safety22-24/25
Risk CodesN/A
Molecular Structure
Hazard SymbolsN/A
SynonymsN/A
Article Data15

Ronidazole Synthetic route

: 263159-60-0
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate

: 7681-76-7
ronidazole

Conditions

Conditions	Yield
With ammonium hydroxide In dichloromethane at 0 - 10℃; for 3h; Inert atmosphere;

: 936-05-0
1-methyl-2-hydroxymethyl-5-nitroimidazole

: 7681-76-7
ronidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: ammonium hydroxide / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere View Scheme

: nickel dibromide

: 7681-76-7
ronidazole

: [Ni(ronidazole)Br2(H2O)2]

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	94%

: nickel(II) chloride hexahydrate

: 7681-76-7
ronidazole

: [Ni(ronidazole)Cl2(H2O)2]

Conditions

Conditions	Yield
In ethanol; acetone for 24h; Reflux;	89%

: 10025-99-7
potassium tetrachloroplatinate(II)

: 7681-76-7
ronidazole

: 84431-22-1
(NO2CCHNC(CH2OC(O)NH2)N(CH3))2PtCl2

Conditions

Conditions	Yield
In water solid ligand added to aq. soln. of K2(PtCl4), stirred at 50 °C for 1 h; ppt. filtered, washed with EtOH/Et2O, Et2O, dried in vac.; elem. anal.;	81%

: 7646-85-7
zinc(II) chloride

: 7681-76-7
ronidazole

: [Zn(ronidazole)Cl2]

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	81%

: zinc dibromide

: 7681-76-7
ronidazole

: [Zn(ronidazole)2Br2]

Conditions

Conditions	Yield
In ethanol; acetone for 4h; Reflux;	78.86%

: copper(II) choride dihydrate

: 7681-76-7
ronidazole

: [Cu(ronidazole)2Cl2]*0.5AcOEt

Conditions

Conditions	Yield
In ethanol; acetone for 24h; Reflux;	78.67%

: 7646-85-7
zinc(II) chloride

: 7681-76-7
ronidazole

: [Zn(ronidazole)2Cl2]

Conditions

Conditions	Yield
In ethanol; acetone for 4h; Reflux;	76.86%

: cadmium chloride tetrahydrate

: 7681-76-7
ronidazole

: [Cd(ronidazole)2Br2]

Conditions

Conditions	Yield
In ethanol; dichloromethane; acetone for 4h; Reflux;	74.96%

Ronidazole Chemical Properties

Molecular Formula: C₆H₈N₄O₄

Formula Weight: 200.15
storage temp. : -20 ^°C
Melting point: 168-169 ^°C
Appearance of Ronidazole (7681-76-7): milky white crystalline powder

Ronidazole Uses

Ronidazole (7681-76-7) is used for antiparasitic immunity.

Ronidazole Toxicity Data With Reference

1.	mmo-sat 3 µg/plate	CBINA8 Chemico-Biological Interactions. 49 (1984),27.
2.	mmo-smc 500 ppm	MUREAV Mutation Research. 86 (1981),243.
3.	orl-rat LD50:3400 mg/kg	VMDNAV Veterinarno-Meditsinski Nauki. 22 (7)(1985),90.
4.	ipr-rat LD50:1500 mg/kg	VMDNAV Veterinarno-Meditsinski Nauki. 22 (7)(1985),90.

Ronidazole Consensus Reports

EPA Genetic Toxicology Program.

Ronidazole Safety Profile

Safety Statements : 22-24/25 (Do not breathe dust; Avoid contact with skin and eyes)
WGK Germany : 2
RTECS : NI6803000
Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also CARBAMATES.

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Product Name

Ronidazole

Ronidazole Synthetic route

Ronidazole Chemical Properties

Ronidazole Uses

Ronidazole Toxicity Data With Reference

Ronidazole Consensus Reports

Ronidazole Safety Profile

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