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| CAS No.: | 131741-08-7 |
|---|---|
| Name: | Simendan |
| Molecular Structure: | |
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| Formula: | C14H12N6O |
| Molecular Weight: | 280.289 |
| Synonyms: | Propanedinitrile,[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]- (9CI);((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile;2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile; |
| Density: | 1.33 g/cm3 |
| PSA: | 113.43000 |
| LogP: | 1.19916 |
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- 52240-11-6
6-(4-aminophenyl)-5-methylpyridazine-3(2H)-one
- 131741-08-7
(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-propanedinitrile
| Conditions | Yield |
|---|---|
| 97% |
- 109-77-3
malononitrile
- 36725-28-7
6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- 131741-08-7
(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-propanedinitrile
| Conditions | Yield |
|---|---|
| With sodium nitrite | |
| With sodium nitrite |
- 110-85-0
piperazine
- 131741-08-7
(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-propanedinitrile
| Conditions | Yield |
|---|---|
| In ethanol at 80℃; for 17.5h; | 76% |
- 131741-08-7
(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-propanedinitrile
A
- 141505-33-1
levosimendan
| Conditions | Yield |
|---|---|
| 1-propanol, poly(vinylpyrrolidone), Tris/Tricine buffer, pH 7.4; |
- 180330-54-5
water ethanol
- 131741-08-7
(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-propanedinitrile
- 74-88-4
methyl iodide
- 131741-28-1
6-[4-(1,1-dicyanomethylidene-N-methylhydrazino)phenyl]-4,5-dihydro-5-methylpyridazin-3(2H)one
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetone |
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Chemistry
IUPAC Name: 2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile
CAS: 131741-08-7
Formula: C14H12N6O
Molecular Weight: 280.28
Molecular Structure of 2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile (131741-08-7):
Water Solubility: 58.06(mg/L) at 25°C
Index of Refraction: 1.673
Molar Refractivity: 78.68 cm3
Molar Volume: 209.8 cm3
Density: 1.33 g/cm3
Polarizability: 31.19 10-24cm3
Surface Tension: 57.1 dyne/cm
Product Categories: The product of 2-[[4-(4-methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile (131741-08-7) is a new class of drugs to enhance myocardial contractile force, belonging to calcium-sensitizing agent, can enhance the calcium sensitivity of myocardial cells, thereby enhancing myocyte contractility.
Uses
The product of 2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile (131741-08-7) is used as an antiemetic drug.
Specification
The chemical synonyms of 2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile (131741-08-7) are 2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile ; ((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile ; Simendan ; Simendan R--[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl] hydrozono]-propanedinitrile ; R-(-)-4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl hydrozono-propanedinitrile .The product of 2-[[4-(4-Methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)phenyl]hydrazinylidene]propanedinitrile (131741-08-7) has well tolerated, with other cardiovascular drugs such as β blockers, ACE inhibitors, calcium antagonists, nitrates, digoxin, warfarin, aspirin, etc. in conjunction with, the more secure . Abroad have been carried out in several large clinical trials, adverse reactions are mild and rarely serious arrhythmia.