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| CAS No.: | 144-83-2 |
|---|---|
| Name: | Sulfapyridine |
| Molecular Structure: | |
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| Formula: | C11H11N3O2S |
| Molecular Weight: | 249.293 |
| Synonyms: | Sulfanilamide,N1-2(1H)-pyridylidene- (6CI,7CI);Sulfanilamide, N1-2-pyridyl- (8CI);Sulfanilamide, N4-2-pyridyl- (4CI);2-Sulfanilamidopyridine;2-Sulfapyridine;4-Amino-N-2-pyridinylbenzenesulfonamide;4-[(2-Pyridylamino)sulfonyl]aniline;A-499;Adiplon;Coccoclase;Dagenan;Eubasin;Eubasinum;Haptocil;M and B 693;N-(2-Pyridyl)-4-aminobenzenesulfonamide;N1-2-Pyridylsulfanilamide;NSC 41791;NSC 4753;Piridazol;Pirodazole;Plurazol;Pyriamid;Pyridazol;Relbapiridina;Ronin;Streptosilpyridine;Sulfapyridine;Sulfidin;Sulphapyridine;Thioseptal;Trianon; |
| EINECS: | 205-642-7 |
| Density: | 1.432 g/cm3 |
| Melting Point: | 191-193 °C |
| Boiling Point: | 473.5 °C at 760 mmHg |
| Flash Point: | 240.2 °C |
| Solubility: | <0.1 g/100 mL at 22 °C in water |
| Appearance: | white or yellowish-white crystalline powder |
| Hazard Symbols: |
 Xi
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| Risk Codes: | 36/37/38 |
| Safety: | 22-24/25-36-26 |
| PSA: | 93.46000 |
| LogP: | 3.19960 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
| Conditions | Yield |
|---|---|
| With iron; ammonium chloride In methanol at 80℃; for 3h; Temperature; Solvent; | 81% |
| With iron; acetic acid | |
| With iron; ammonium chloride In methanol; water at 70℃; for 4h; | |
| With sodium hydroxide; water; iron(II) sulfate |
| Conditions | Yield |
|---|---|
| With N,N-dimethyl-aniline at 180℃; |
- 504-29-0
2-aminopyridine
- 101570-35-8
3-(4-acetylamino-benzenesulfonyl)-2-benzenesulfonylimino-2,3-dihydro-thiazole
- 144-83-2
sulphapyridine
| Conditions | Yield |
|---|---|
| With pyridine; sodium hydroxide; water |
| Conditions | Yield |
|---|---|
| at 140℃; | |
| Stage #1: 2-aminopyridine; p-acetylaminobenzenesulfonyl chloride With pyridine In tetrahydrofuran at 20℃; for 6h; Stage #2: With sodium hydroxide for 2h; Reflux; |
| Conditions | Yield |
|---|---|
| With copper; potassium carbonate at 180℃; |
| Conditions | Yield |
|---|---|
| With copper; potassium carbonate at 150℃; |
| Conditions | Yield |
|---|---|
| With ammonia; water; copper; copper dichloride at 150 - 160℃; | |
| With ammonia; water; copper(l) chloride at 150 - 175℃; |
- 99360-04-0
4-(butanoylamino)benzenesulfonyl chloride
- 40825-17-0
Natrium-Verbindung des [2]Pyridylamins
- 144-83-2
sulphapyridine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water; Petroleum ether |
- 19077-98-6
N-acetylsulfapyridine
- 144-83-2
sulphapyridine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water | |
| With calcium hydroxide; water | |
| With hydrogenchloride; water at 60℃; |
- 41162-19-0Phosphonic acid,P-(2-oxo-4-phenylbutyl)-, dimethyl ester
- 20633-67-4Calycosin-7-O-beta-D-glucoside
- 5188-07-8Methanethiol, sodiumsalt (1:1)
- 13731-82-31,4-Benzenedicarboxylicacid, 2,5-dibromo-
- 106-28-5(E,E)-Farnesol
- 9004-36-8Cellulose, acetate butanoate
- 862189-95-54H-Pyrrolo[3,2-d]pyrimidin-4-one,5-ethyl-3,5-dihydro-2-[5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]-2-propoxyphenyl]-7-propyl-
- 110-77-0Ethanol, 2-(ethylthio)-
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
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Consensus Reports
Reported in EPA TSCA Inventory.
Specification
Sulfapyridine, with the CAS registry number 144-83-2, it is also named as 2-(p-Aminobenzenesulphonamido)pyridine. The product's categories are Aromatics Compounds; Aromatics; Sulfur & Selenium Compounds. It is white or yellowish-white crystalline powder which is stable, combustible, potentially toxic and incompatible with strong oxidizing agents. What's more, this chemical can be obtained by condensation and hydrolysis of 2-aminopyridine. Additionally, it should be stored at the temperature of 2-8 °C.
Physical properties about Sulfapyridine are: (1)ACD/LogP: 0.469; (2)ACD/LogD (pH 5.5): 0.47; (3)ACD/LogD (pH 7.4): 0.41; (4)ACD/BCF (pH 5.5): 1.34; (5)ACD/BCF (pH 7.4): 1.16; (6)ACD/KOC (pH 5.5): 42.77; (7)ACD/KOC (pH 7.4): 37.14; (8)#H bond acceptors: 5; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.674; (12)Molar Refractivity: 65.348 cm3; (13)Molar Volume: 174.056 cm3; (14)Polarizability: 25.906 10-24cm3; (15)Surface Tension: 73.056999206543 dyne/cm; (16)Density: 1.432 g/cm3; (17)Flash Point: 240.188 °C; (18)Enthalpy of Vaporization: 73.669 kJ/mol; (19)Boiling Point: 473.538 °C at 760 mmHg
Uses of Sulfapyridine: It is antibacterial which is used to treat certain skin diseases. But it is not prescribed for treatment in humans any more. And it is also used as pharmaceutical intermediate.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin, so people should not breathe dust and avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.
People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(Nc1ncccc1)c2ccc(N)cc2
2. InChI:InChI=1/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
The following are the toxicity data which has been tested.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 500mg/kg (500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 454, 1939. |
| mouse | LD50 | intraperitoneal | 1150mg/kg (1150mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archivum Immunologiae et Therapiae Experimentalis. Vol. 16, Pg. 804, 1968. |
| mouse | LD50 | oral | 16600mg/kg (16600mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TREMOR | Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938. |
| rabbit | LDLo | oral | 20gm/kg (20000mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 62, Pg. 281, 1939. |
| rat | LD50 | intravenous | 800mg/kg (800mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950. | |
| rat | LD50 | oral | 15800mg/kg (15800mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE | Quarterly Journal of Pharmacy & Pharmacology. Vol. 11, Pg. 217, 1938. |