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| Name |
Surmontil maleate |
EINECS | N/A |
| CAS No. | 521-78-8 | Density | 1.029g/cm3 |
| PSA | 81.08000 | LogP | 3.89780 |
| Solubility | N/A | Melting Point |
141-143°C |
| Formula | C20H26N2•C4H4O4 | Boiling Point | 411.8°Cat760mmHg |
| Molecular Weight | 410.56 | Flash Point | 183.3°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | 22-36/37/38-63-36/38-23/25-39/23/24/25-23/24/25-11 |
| Molecular Structure |
|
Hazard Symbols | Xn,T,F |
| Synonyms |
trimipraminehydrogenmaleate |
Surmontil maleate Chemical Properties
IUPAC Name: But-2-enedioic acid; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethyl-propan-1-amine
Synonyms: 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine (2Z)-but-2-enedioate (1:1) ; 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (2Z)-2-butenedioate (1:1) ; 10,11-Dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine (Z)-2-butenedioate (1:1)
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Biogenic Amine Transport Inhibitors;Biogenic Amine Transport InhibitorsObesity Research;Neurotransmission;Neurotransmission (Obesity);Neurotransmitters
CAS NO: 521-78-8
Molecular Formula of Surmontil maleate (CAS NO.521-78-8) :C24H30N2O4
Molecular Weight of Surmontil maleate (CAS NO.521-78-8) : 410.51
Molecular Structure of Surmontil maleate (CAS NO.521-78-8) : 
EINECS: 208-318-3
Flash Point: 183.3 °C
Enthalpy of Vaporization: 66.43 kJ/mol
Boiling Point: 411.8 °C at 760 mmHg
Vapour Pressure: 5.45E-07 mmHg at 25°C
Melting point: 141-143°C
Storage temp: 2-8°C
Appearance:White Crystalline Solid
Surmontil maleate Uses
Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake
Surmontil maleate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 223mg/kg (223mg/kg) | Drugs in Japan Vol. -, Pg. 876, 1995. | |
| mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| mouse | LD50 | intravenous | 40mg/kg (40mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| mouse | LD50 | oral | 425mg/kg (425mg/kg) | Drugs in Japan Vol. 6, Pg. 526, 1982. | |
| mouse | LD50 | subcutaneous | 240mg/kg (240mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rabbit | LD50 | intravenous | 27mg/kg (27mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965. |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rat | LD50 | intravenous | 38mg/kg (38mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rat | LD50 | oral | 800mg/kg (800mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970. | |
| rat | LD50 | subcutaneous | 308mg/kg (308mg/kg) | Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970 |
Surmontil maleate Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes 
Xn,
T,
F
Risk Statements 22-36/37/38-63-23/25
R22:Harmful if swallowed.
R23/25:Toxic by inhalation and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R63:Possible risk of harm to the unborn child.
Safety Statements 26-36-45-33-24-16-7
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S33:Take precautionary measures against static discharges.
S24:Avoid contact with skin.
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
RIDADR 3249
WGK Germany 3
RTECS HN9260000
HazardClass 6.1(b)
PackingGroup III
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