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Name |
TETRAMETHYLSUCCINONITRILE |
EINECS | N/A |
CAS No. | 3333-52-6 | Density | 0.923g/cm3 |
PSA | 47.58000 | LogP | 2.08596 |
Solubility | Insoluble in water | Melting Point |
168°C |
Formula | C8H12 N2 | Boiling Point | 264.2°Cat760mmHg |
Molecular Weight | 136.197 | Flash Point | 116.4°C |
Transport Information | N/A | Appearance | N/A |
Safety | Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. A human skin irritant and allergen. In the preparation of sponge rubber, an azo compound is used that decomposes to form tetramethylsuccinonitrile or TMSN. Rats exposed to a concentration of 90 ppm exhibit their first convulsion after 1.5–2 hours or less. Rats exposed to concentration of 5.5 ppm exhibited their first convulsions in 27–31 hours and were dead in 31–46 hours. Absorbed by skin. The fatal dose in humans is thought to be about 25 mg/kg of body weight. TSN is slowly detoxified by the body. This nitrile is different from other nitriles in that thiosulfate is a poor antidote for intoxication. When heated to decomposition it emits toxic fumes of CN− and NOx. See also NITRILES and CYANIDE. | Risk Codes | 23/24/25-36/37/38-48/20/21 |
Molecular Structure | Hazard Symbols | Toxic by inhalation and skin contact. TLV: 0.5 ppm. | |
Synonyms |
Butanedinitrile,tetramethyl- (9CI); Succinonitrile, tetramethyl- (6CI,7CI,8CI);2,2,3,3-Tetramethylbutanedinitrile; 2,2,3,3-Tetramethylsuccinonitrile;2,3-Dicyano-2,3-dimethylbutane; NSC 39746; Tetramethylsuccinic acid dinitrile;Tetramethylsuccinodinitrile; Tetramethylsuccinonitrile |
Article Data | 18 |
1. | ipr-ham TDLo:9944 µg/kg (8D preg):TER | FAATDF Fundamental and Applied Toxicology. 3 (1983),41. | ||
2. | orl-rat LD50:38,900 µg/kg | FAATDF Fundamental and Applied Toxicology. 7 (1986),41. | ||
3. | ipr-mus LD50:17,710 µg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 223 (1982),635. | ||
4. | ivn-mus LD50:18 mg/kg | CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#00002 . |