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Cas Database |
| Name |
TRIS(2-CHLOROETHYL)AMMONIUM CHLORIDE |
EINECS | N/A |
| CAS No. | 817-09-4 | Density | N/A |
| PSA | 3.24000 | LogP | 2.80680 |
| Solubility | N/A | Melting Point |
127-130 °C(lit.) |
| Formula | C6H12 Cl3 N . Cl H | Boiling Point | 156.2°C at 760 mmHg |
| Molecular Weight | 240.988 | Flash Point | 48.3°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion and intravenous routes: somnolence, anorexia, headache, thrombosis distant from injection site, nausea or vomiting, and leukopenia. Experimental reproductive effects. Mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of Cl−, NH3, and NOx. Used as an antineoplastic agent. | Risk Codes | 28-34-40 |
| Molecular Structure |
|
Hazard Symbols |
 
|
| Synonyms |
Ethanamine,2-chloro-N,N-bis(2-chloroethyl)-, hydrochloride (9CI); Triethylamine, 2,2',2''-trichloro-,hydrochloride (8CI); 2,2',2''-Trichlorotriethylamine hydrochloride;2-Chloro-N,N-bis(2-chloroethyl)ethanammonium chloride; NSC 30211; R 47;Sinalost; Tri(2-chloroethyl)amine hydrochloride; Tri(b-chloroethyl)amine hydrochloride;Trichlormethin; Trillekamin; Trimitan; Trimustine; Tris(2-chloroethyl)aminehydrochloride; Tris(b-chloroethyl)amine hydrochloride |
Article Data | 27 |
TRIS(2-CHLOROETHYL)AMMONIUM CHLORIDE Chemical Properties
Product Name: Tris(2-chloroethyl)ammonium chloride (CAS NO.817-09-4)
Molecular Formula: C6H13Cl4N
Molecular Weight: 240.99g/mol
Mol File: 817-09-4.mol
Einecs: 212-442-3
Appearance: White to off-white crystalline powder
Melting Point: 127-130 °C(lit.)
Boiling point: 156.2 °C at 760 mmHg
Storage Temperature: Poison room
Flash Point: 48.3 °C
Enthalpy of Vaporization: 39.29 kJ/mol
Vapour Pressure: 2.92 mmHg at 25°C
H-Bond Donor: 1
H-Bond Acceptor: 1
Product Categories: Amine Salts; Nitrogen Compounds; Organic Building Blocks
TRIS(2-CHLOROETHYL)AMMONIUM CHLORIDE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD75 | intravenous | 1mg/kg (1mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 277, 1947. |
| human | TDLo | intravenous | 100ug/kg (0.1mg/kg) | BEHAVIORAL: HEADACHE VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE GASTROINTESTINAL: NAUSEA OR VOMITING | National Technical Information Service. Vol. PB158-507, |
| human | TDLo | oral | 30ug/kg (0.03mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING | National Technical Information Service. Vol. PB158-507, |
| human | TDLo | oral | 214ug/kg (0.214mg/kg) | BLOOD: LEUKOPENIA | National Technical Information Service. Vol. PB158-507, |
| mouse | LD50 | intraperitoneal | 1600ug/kg (1.6mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 559, 1957. | |
| mouse | LD50 | oral | 1100ug/kg (1.1mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 595, 1959. | |
| mouse | LD50 | subcutaneous | 2mg/kg (2mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947. | |
| rabbit | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947. | |
| rabbit | LDLo | oral | 2mg/kg (2mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 247, 1946. |
| rat | LD50 | intraperitoneal | 750ug/kg (0.75mg/kg) | Chemical and Pharmaceutical Bulletin. Vol. 8, Pg. 807, 1960. | |
| rat | LD50 | intravenous | 700ug/kg (0.7mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LD50 | subcutaneous | 2mg/kg (2mg/kg) | National Technical Information Service. Vol. PB158-507, | |
| rat | LDLo | oral | 5mg/kg (5mg/kg) | National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 19, 1953. |
TRIS(2-CHLOROETHYL)AMMONIUM CHLORIDE Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 ,1975,p. 229.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
TRIS(2-CHLOROETHYL)AMMONIUM CHLORIDE Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion and intravenous routes: somnolence, anorexia, headache, thrombosis distant from injection site, nausea or vomiting, and leukopenia. Experimental reproductive effects. Mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of Cl−, NH3, and NOx. Used as an antineoplastic agent.
Safety Information of Tris(2-chloroethyl)ammonium chloride (CAS NO.817-09-4):
Hazard Codes: T+.gif){kind=small}
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Risk Statements: 28-34-40
28: Very Toxic if swallowed
34: Causes burns
40: Limited evidence of a carcinogenic effect
Safety Statements: 26-28-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
TRIS(2-CHLOROETHYL)AMMONIUM CHLORIDE Specification
Tris(2-chloroethyl)ammonium chloride ,its CAS NO. is 817-09-4,the synonyms is Tris(2-chloroethyl)amine hydrochloride ; b,b',b''-Trichlorotriethylamine hydrochloride ; 2,2',2''-Trichlorotriethylamine hydrochloride ; 2,2',2"-Trichloro-triethylaminhydrochloride ; 2-Chloro-n,n-bis(2-chloroethyl)-ethanaminhydrochloride ; Ethanamine,2-chloro-n,n-bis[2-chloroethyl]-,hydrochloride ; Hn3hydrochloride ; Lekamin .
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