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Isobutyric acid (2R,3S,5R)-5-(2-isobutyrylamino-6-thioxo-1,6-dihydro-purin-9-yl)-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol | 100% |
2'-Deoxyguanosine
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
With sodium hydrogensulfide; trifluoroacetic anhydride In pyridine; N,N-dimethyl-formamide | 65% |
With pyridine; sodium hydrogensulfide; trifluoroacetic anhydride 1) 40 min, ice-bath, 2) DMF, 24 h; Yield given. Multistep reaction; |
2-Amino-6-chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
With hydrogen sulfide; sodium methylate 1) anhydr. MeOH, reflux, 2 h; 2) MeOH, reflux, 1 h; Yield given. Multistep reaction; |
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 30 min; 2) acetonitrile, 20 h 2: 1) H2S/1M sodium methoxide; 2) 1M sodium methoxide / 1) anhydr. MeOH, reflux, 2 h; 2) MeOH, reflux, 1 h View Scheme |
2-Amino-6-chloropurin
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 30 min; 2) acetonitrile, 20 h 2: 1) H2S/1M sodium methoxide; 2) 1M sodium methoxide / 1) anhydr. MeOH, reflux, 2 h; 2) MeOH, reflux, 1 h View Scheme |
2'-deoxy-N2-isobutyrylguanosine 3',5'-diisobutyrate
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1. triethylamine, dimethylaminopyridine, mesitylenesulphonyl chloride, 2a. N-methyl pyrrolidine, 2b. thiolacetic acid / 1. CH2Cl2, RT, 2a. ice bath, 2b. 30 min 2: 100 percent / 2 M NaOH / ethanol View Scheme |
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine-6-sulfenamide
Conditions | Yield |
---|---|
With potassium hydroxide; sodium hydroxide; sodium hypochlorite In water 0 deg C to RT; | 86% |
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
2-amino-9-(β-D-2'-deoxyribofuranosyl)-purine
Conditions | Yield |
---|---|
nickel In ethanol; water desulfuration; Heating; | 77% |
With nickel | 75% |
With nickel In water at 50℃; for 13h; | 73% |
Conditions | Yield |
---|---|
Stage #1: 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine With phosphorous acid trimethyl ester; trichlorophosphate at 0℃; for 3h; phosphorylation; Stage #2: triethylamine With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate In N,N-dimethyl-formamide pH=7.0; phosphorylation; | 38% |
2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercapto-9H-purine
Conditions | Yield |
---|---|
In methanol at 60℃; for 24h; | 31% |
IUPAC Name: 2-Amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
Molecular Formula: C10H13N5O3S
Molecular Weight: 283.34g/mol
Freely Rotating Bonds: 4
Polar Surface Area: 96.44 Å2
Index of Refraction: 1.93
Molar Refractivity: 66.43 cm3
Molar Volume: 139.5 cm3
Polarizability: 26.33 ×10-24cm3
Surface Tension: 95.1 dyne/cm
Density: 2.02 g/cm3
Flash Point: 382.6 °C
Enthalpy of Vaporization: 108.88 kJ/mol
Boiling Point: 709.1 °C at 760 mmHg
Vapour Pressure: 4.22E-21 mmHg at 25°C
The Cas Register Number of Thioguanine deoxyriboside is 789-61-7 .The chemical synonyms of Thioguanine deoxyriboside (CAS No.789-61-7) are 2’-Deoxy-6-thio-guanosin ; 2’-Deoxythioguanosine ; 2-Amino-9-(2-deoxy-beta-d-erythro-pentofuranosyl)-9h-purine-6(1h)-thion ; Beta-2’-deoxythioguanosine ; Beta-thioguaninedeoxyriboside ; Nci-c01581 ; Tgdr ; 6-Thio-2'-deoxyguanosine .The molecular structure of Thioguanine deoxyriboside (CAS No.789-61-7) is.
NCI Carcinogenesis Bioassay (ipr). clear evidence: rat, NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-57 ,1978. ; NCI Carcinogenesis Bioassay (ipr). inadequate studies:mouse, NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-TR-57 ,1978.
Questionable carcinogen with experimental carcinogenic data reported. When heated to decomposition it emits toxic vapors of NOx and SOx.
The extinguishing agent of Thioguanine deoxyriboside (CAS No.789-61-7) are dry powder, foam, sand, carbon dioxide, water mist.